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Covalent inhibition of pro-apoptotic BAX.
McHenry MW, Shi P, Camara CM, Cohen DT, Rettenmaier TJ, Adhikary U, Gygi MA, Yang K, Gygi SP, Wales TE, Engen JR, Wells JA, Walensky LD. McHenry MW, et al. Among authors: cohen dt. Nat Chem Biol. 2024 Jan 17. doi: 10.1038/s41589-023-01537-6. Online ahead of print. Nat Chem Biol. 2024. PMID: 38233584
Allosteric sensitization of proapoptotic BAX.
Pritz JR, Wachter F, Lee S, Luccarelli J, Wales TE, Cohen DT, Coote P, Heffron GJ, Engen JR, Massefski W, Walensky LD. Pritz JR, et al. Among authors: cohen dt. Nat Chem Biol. 2017 Sep;13(9):961-967. doi: 10.1038/nchembio.2433. Epub 2017 Jul 10. Nat Chem Biol. 2017. PMID: 28692068 Free PMC article.
Identification of a Covalent Molecular Inhibitor of Anti-apoptotic BFL-1 by Disulfide Tethering.
Harvey EP, Hauseman ZJ, Cohen DT, Rettenmaier TJ, Lee S, Huhn AJ, Wales TE, Seo HS, Luccarelli J, Newman CE, Guerra RM, Bird GH, Dhe-Paganon S, Engen JR, Wells JA, Walensky LD. Harvey EP, et al. Among authors: cohen dt. Cell Chem Biol. 2020 Jun 18;27(6):647-656.e6. doi: 10.1016/j.chembiol.2020.04.004. Epub 2020 May 14. Cell Chem Biol. 2020. PMID: 32413285 Free PMC article.
Allosteric inhibition of antiapoptotic MCL-1.
Lee S, Wales TE, Escudero S, Cohen DT, Luccarelli J, Gallagher CG, Cohen NA, Huhn AJ, Bird GH, Engen JR, Walensky LD. Lee S, et al. Among authors: cohen dt, cohen na. Nat Struct Mol Biol. 2016 Jun;23(6):600-7. doi: 10.1038/nsmb.3223. Epub 2016 May 9. Nat Struct Mol Biol. 2016. PMID: 27159560 Free PMC article.
Homogeneous Oligomers of Pro-apoptotic BAX Reveal Structural Determinants of Mitochondrial Membrane Permeabilization.
Hauseman ZJ, Harvey EP, Newman CE, Wales TE, Bucci JC, Mintseris J, Schweppe DK, David L, Fan L, Cohen DT, Herce HD, Mourtada R, Ben-Nun Y, Bloch NB, Hansen SB, Wu H, Gygi SP, Engen JR, Walensky LD. Hauseman ZJ, et al. Among authors: cohen dt. Mol Cell. 2020 Jul 2;79(1):68-83.e7. doi: 10.1016/j.molcel.2020.05.029. Epub 2020 Jun 12. Mol Cell. 2020. PMID: 32533918 Free PMC article.
32 results