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Potent antibody-dependent cellular cytotoxicity of a V2-specific antibody is not sufficient for protection of macaques against SIV challenge.
Grunst MW, Gil HM, Grandea AG 3rd, Snow BJ, Andrabi R, Nedellec R, Burton I, Clark NM, Janaka SK, Keles NK, Moriarty RV, Weiler AM, Capuano S 3rd, Fennessey CM, Friedrich TC, O'Connor SL, O'Connor DH, Broman AT, Keele BF, Lifson JD, Hangartner L, Burton DR, Evans DT. Grunst MW, et al. Among authors: keele bf. PLoS Pathog. 2024 Jan 22;20(1):e1011819. doi: 10.1371/journal.ppat.1011819. eCollection 2024 Jan. PLoS Pathog. 2024. PMID: 38252675 Free PMC article.
CD8+ cells and small viral reservoirs facilitate post-ART control of SIV in Mauritian cynomolgus macaques.
Harwood OE, Matschke LM, Moriarty RV, Balgeman AJ, Weaver AJ, Ellis-Connell AL, Weiler AM, Winchester LC, Fletcher CV, Friedrich TC, Keele BF, O'Connor DH, Lang JD, Reynolds MR, O'Connor SL. Harwood OE, et al. Among authors: keele bf. bioRxiv [Preprint]. 2023 Mar 2:2023.03.01.530655. doi: 10.1101/2023.03.01.530655. bioRxiv. 2023. PMID: 36909458 Free PMC article. Updated. Preprint.
Lymphoid tissues contribute to viral clonotypes present in plasma at early post-ATI in SIV-infected rhesus macaques.
Solis-Leal A, Boby N, Mallick S, Cheng Y, Wu F, De La Torre G, Dufour J, Alvarez X, Shivanna V, Liu Y, Fennessey CM, Lifson JD, Li Q, Keele BF, Ling B. Solis-Leal A, et al. Among authors: keele bf. bioRxiv [Preprint]. 2023 May 30:2023.05.30.542512. doi: 10.1101/2023.05.30.542512. bioRxiv. 2023. PMID: 37398418 Free PMC article. Updated. Preprint.
TGF-β blockade drives a transitional effector phenotype in T cells reversing SIV latency and decreasing SIV reservoirs in vivo.
Kime J, Bose D, Arainga M, Haque MR, Fennessey CM, Caddell RA, Thomas Y, Ferrell DE, Ali S, Grody E, Goyal Y, Cicala C, Arthos J, Keele BF, Vaccari M, Lorenzo-Redondo R, Hope TJ, Villinger FJ, Marinelli E. Kime J, et al. Among authors: keele bf. bioRxiv [Preprint]. 2023 Dec 15:2023.09.05.556422. doi: 10.1101/2023.09.05.556422. bioRxiv. 2023. PMID: 38014094 Free PMC article. Updated. Preprint.
Early antiretroviral therapy in SIV-infected rhesus macaques reveals a multiphasic, saturable dynamic accumulation of the rebound competent viral reservoir.
Keele BF, Okoye AA, Fennessey CM, Varco-Merth B, Immonen TT, Kose E, Conchas A, Pinkevych M, Lipkey L, Newman L, Macairan A, Bosche M, Bosche WJ, Berkemeier B, Fast R, Hull M, Oswald K, Shoemaker R, Silipino L, Gorelick RJ, Duell D, Marenco A, Brantley W, Smedley J, Axthelm M, Davenport MP, Lifson JD, Picker LJ. Keele BF, et al. PLoS Pathog. 2024 Apr 9;20(4):e1012135. doi: 10.1371/journal.ppat.1012135. eCollection 2024 Apr. PLoS Pathog. 2024. PMID: 38593120 Free PMC article.
TGF-β blockade drives a transitional effector phenotype in T cells reversing SIV latency and decreasing SIV reservoirs in vivo.
Kim J, Bose D, Araínga M, Haque MR, Fennessey CM, Caddell RA, Thomas Y, Ferrell DE, Ali S, Grody E, Goyal Y, Cicala C, Arthos J, Keele BF, Vaccari M, Lorenzo-Redondo R, Hope TJ, Villinger F, Martinelli E. Kim J, et al. Among authors: keele bf. Nat Commun. 2024 Feb 14;15(1):1348. doi: 10.1038/s41467-024-45555-x. Nat Commun. 2024. PMID: 38355731 Free PMC article.
Lymphoid tissues contribute to plasma viral clonotypes early after antiretroviral therapy interruption in SIV-infected rhesus macaques.
Solis-Leal A, Boby N, Mallick S, Cheng Y, Wu F, De La Torre G, Dufour J, Alvarez X, Shivanna V, Liu Y, Fennessey CM, Lifson JD, Li Q, Keele BF, Ling B. Solis-Leal A, et al. Among authors: keele bf. Sci Transl Med. 2023 Dec 13;15(726):eadi9867. doi: 10.1126/scitranslmed.adi9867. Epub 2023 Dec 13. Sci Transl Med. 2023. PMID: 38091409
Preferential selection of viral escape mutants by CD8+ T cell 'sieving' of SIV reactivation from latency.
Docken SS, McCormick K, Pampena MB, Samer S, Lindemuth E, Pinkevych M, Viox EG, Wu Y, Schlub TE, Cromer D, Keele BF, Paiardini M, Betts MR, Bar KJ, Davenport MP. Docken SS, et al. Among authors: keele bf. PLoS Pathog. 2023 Nov 30;19(11):e1011755. doi: 10.1371/journal.ppat.1011755. eCollection 2023 Nov. PLoS Pathog. 2023. PMID: 38032851 Free PMC article.
CD8+ cells and small viral reservoirs facilitate post-ART control of SIV replication in M3+ Mauritian cynomolgus macaques initiated on ART two weeks post-infection.
Harwood OE, Matschke LM, Moriarty RV, Balgeman AJ, Weaver AJ, Ellis-Connell AL, Weiler AM, Winchester LC, Fletcher CV, Friedrich TC, Keele BF, O'Connor DH, Lang JD, Reynolds MR, O'Connor SL. Harwood OE, et al. Among authors: keele bf. PLoS Pathog. 2023 Sep 25;19(9):e1011676. doi: 10.1371/journal.ppat.1011676. eCollection 2023 Sep. PLoS Pathog. 2023. PMID: 37747933 Free PMC article.
199 results