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Page 1
Discovery and SAR Study of Boronic Acid-Based Selective PDE3B Inhibitors from a Novel DNA-Encoded Library.
Rowley AM, Yao G, Andrews L, Bedermann A, Biddulph R, Bingham R, Brady JJ, Buxton R, Cecconie T, Cooper R, Csakai A, Gao EN, Grenier-Davies MC, Lawler M, Lian Y, Macina J, Macphee C, Marcaurelle L, Martin J, McCormick P, Pindoria R, Rauch M, Rocque W, Shen Y, Shewchuk LM, Squire M, Stebbeds W, Tear W, Wang X, Ward P, Xiao S. Rowley AM, et al. Among authors: macina j. J Med Chem. 2024 Feb 8;67(3):2049-2065. doi: 10.1021/acs.jmedchem.3c01562. Epub 2024 Jan 29. J Med Chem. 2024. PMID: 38284310
Evaluation of a Three-Dimensional Primary Human Hepatocyte Spheroid Model: Adoption and Industrialization for the Enhanced Detection of Drug-Induced Liver Injury.
Schofield CA, Walker TM, Taylor MA, Patel M, Vlachou DF, Macina JM, Vidgeon-Hart MP, Williams A, McGill PJ, Newman CF, Sakatis MZ. Schofield CA, et al. Among authors: macina jm. Chem Res Toxicol. 2021 Dec 20;34(12):2485-2499. doi: 10.1021/acs.chemrestox.1c00227. Epub 2021 Nov 19. Chem Res Toxicol. 2021. PMID: 34797640
HDAC3 Regulates Gingival Fibroblast Inflammatory Responses in Periodontitis.
Lagosz KB, Bysiek A, Macina JM, Bereta GP, Kantorowicz M, Lipska W, Sochalska M, Gawron K, Kaczmarzyk T, Chomyszyn-Gajewska M, Fossati G, Potempa J, Grabiec AM. Lagosz KB, et al. Among authors: macina jm. J Dent Res. 2020 Jan;99(1):98-106. doi: 10.1177/0022034519885088. Epub 2019 Nov 6. J Dent Res. 2020. PMID: 31693860 Free PMC article.
BET Bromodomain Inhibitors Suppress Inflammatory Activation of Gingival Fibroblasts and Epithelial Cells From Periodontitis Patients.
Maksylewicz A, Bysiek A, Lagosz KB, Macina JM, Kantorowicz M, Bereta G, Sochalska M, Gawron K, Chomyszyn-Gajewska M, Potempa J, Grabiec AM. Maksylewicz A, et al. Among authors: macina jm. Front Immunol. 2019 Apr 30;10:933. doi: 10.3389/fimmu.2019.00933. eCollection 2019. Front Immunol. 2019. PMID: 31114581 Free PMC article.