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VEXAS syndrome is characterized by inflammasome activation and monocyte dysregulation.
Kosmider O, Possémé C, Templé M, Corneau A, Carbone F, Duroyon E, Breillat P, Chirayath TW, Oules B, Sohier P, Luka M, Gobeaux C, Lazaro E, Outh R, Le Guenno G, Lifermann F, Berleur M, Le Mene M, Friedrich C, Lenormand C, Weitten T, Guillotin V, Burroni B, Boussier J, Willems L, Aractingi S, Dionet L, Tharaux PL, Vergier B, Raynaud P, Ea HK, Ménager M, Duffy D, Terrier B. Kosmider O, et al. Among authors: tharaux pl. Nat Commun. 2024 Jan 30;15(1):910. doi: 10.1038/s41467-024-44811-4. Nat Commun. 2024. PMID: 38291039 Free PMC article.
Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients.
Hadjadj J, Yatim N, Barnabei L, Corneau A, Boussier J, Smith N, Péré H, Charbit B, Bondet V, Chenevier-Gobeaux C, Breillat P, Carlier N, Gauzit R, Morbieu C, Pène F, Marin N, Roche N, Szwebel TA, Merkling SH, Treluyer JM, Veyer D, Mouthon L, Blanc C, Tharaux PL, Rozenberg F, Fischer A, Duffy D, Rieux-Laucat F, Kernéis S, Terrier B. Hadjadj J, et al. Among authors: tharaux pl. Science. 2020 Aug 7;369(6504):718-724. doi: 10.1126/science.abc6027. Epub 2020 Jul 13. Science. 2020. PMID: 32661059 Free PMC article.
Severe COVID-19 is associated with hyperactivation of the alternative complement pathway.
Boussier J, Yatim N, Marchal A, Hadjadj J, Charbit B, El Sissy C, Carlier N, Pène F, Mouthon L, Tharaux PL, Bergeron A, Smadja DM, Rieux-Laucat F, Duffy D, Kernéis S, Frémeaux-Bacchi V, Terrier B. Boussier J, et al. Among authors: tharaux pl. J Allergy Clin Immunol. 2022 Feb;149(2):550-556.e2. doi: 10.1016/j.jaci.2021.11.004. Epub 2021 Nov 17. J Allergy Clin Immunol. 2022. PMID: 34800432 Free PMC article.
160 results