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Antibody agonists trigger immune receptor signaling through local exclusion of receptor-type protein tyrosine phosphatases.
Lippert AH, Paluch C, Gaglioni M, Vuong MT, McColl J, Jenkins E, Fellermeyer M, Clarke J, Sharma S, Moreira da Silva S, Akkaya B, Anzilotti C, Morgan SH, Jessup CF, Körbel M, Gileadi U, Leitner J, Knox R, Chirifu M, Huo J, Yu S, Ashman N, Lui Y, Wilkinson I, Attfield KE, Fugger L, Robertson NJ, Lynch CJ, Murray L, Steinberger P, Santos AM, Lee SF, Cornall RJ, Klenerman D, Davis SJ. Lippert AH, et al. Among authors: davis sj. Immunity. 2024 Feb 13;57(2):256-270.e10. doi: 10.1016/j.immuni.2024.01.007. Immunity. 2024. PMID: 38354703 Free article.
Initiation of T cell signaling by CD45 segregation at 'close contacts'.
Chang VT, Fernandes RA, Ganzinger KA, Lee SF, Siebold C, McColl J, Jönsson P, Palayret M, Harlos K, Coles CH, Jones EY, Lui Y, Huang E, Gilbert RJC, Klenerman D, Aricescu AR, Davis SJ. Chang VT, et al. Among authors: davis sj. Nat Immunol. 2016 May;17(5):574-582. doi: 10.1038/ni.3392. Epub 2016 Mar 21. Nat Immunol. 2016. PMID: 26998761 Free PMC article.
Immune Checkpoints as Therapeutic Targets in Autoimmunity.
Paluch C, Santos AM, Anzilotti C, Cornall RJ, Davis SJ. Paluch C, et al. Among authors: davis sj. Front Immunol. 2018 Oct 8;9:2306. doi: 10.3389/fimmu.2018.02306. eCollection 2018. Front Immunol. 2018. PMID: 30349540 Free PMC article. Review.
Antigen discrimination by T cells relies on size-constrained microvillar contact.
Jenkins E, Körbel M, O'Brien-Ball C, McColl J, Chen KY, Kotowski M, Humphrey J, Lippert AH, Brouwer H, Santos AM, Lee SF, Davis SJ, Klenerman D. Jenkins E, et al. Among authors: davis sj. Nat Commun. 2023 Mar 23;14(1):1611. doi: 10.1038/s41467-023-36855-9. Nat Commun. 2023. PMID: 36959206 Free PMC article.
The T cell receptor triggering apparatus is composed of monovalent or monomeric proteins.
James JR, McColl J, Oliveira MI, Dunne PD, Huang E, Jansson A, Nilsson P, Sleep DL, Gonçalves CM, Morgan SH, Felce JH, Mahen R, Fernandes RA, Carmo AM, Klenerman D, Davis SJ. James JR, et al. Among authors: davis sj. J Biol Chem. 2011 Sep 16;286(37):31993-2001. doi: 10.1074/jbc.M111.219212. Epub 2011 Jul 13. J Biol Chem. 2011. PMID: 21757710 Free PMC article.
500 results