Guy RK - Search Results

1

Carrillo AK, Kadayat TM, Hwang JY, Chen Y, Zhu F, Holbrook G, Gillingwater K, Connelly MC, Yang L, Kaiser M, Guy RK. Carrillo AK, et al. Among authors: guy rk. J Med Chem. 2024 Mar 14;67(5):3437-3447. doi: 10.1021/acs.jmedchem.3c01680. Epub 2024 Feb 16. J Med Chem. 2024. PMID: 38363074

2

Optimization of chloronitrobenzamides (CNBs) as therapeutic leads for human African trypanosomiasis (HAT).

Hwang JY, Smithson D, Zhu F, Holbrook G, Connelly MC, Kaiser M, Brun R, Guy RK. Hwang JY, et al. Among authors: guy rk. J Med Chem. 2013 Apr 11;56(7):2850-60. doi: 10.1021/jm301687p. Epub 2013 Mar 26. J Med Chem. 2013. PMID: 23484493

3

Discovery of an Orally Bioavailable Inhibitor of Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation.

Hammill JT, Bhasin D, Scott DC, Min J, Chen Y, Lu Y, Yang L, Kim HS, Connelly MC, Hammill C, Holbrook G, Jeffries C, Singh B, Schulman BA, Guy RK. Hammill JT, et al. Among authors: guy rk. J Med Chem. 2018 Apr 12;61(7):2694-2706. doi: 10.1021/acs.jmedchem.7b01282. Epub 2018 Mar 26. J Med Chem. 2018. PMID: 29547693 Free PMC article.

4

Improvement of pharmacological properties of irreversible thyroid receptor coactivator binding inhibitors.

Hwang JY, Arnold LA, Zhu F, Kosinski A, Mangano TJ, Setola V, Roth BL, Guy RK. Hwang JY, et al. Among authors: guy rk. J Med Chem. 2009 Jul 9;52(13):3892-901. doi: 10.1021/jm9002704. J Med Chem. 2009. PMID: 19469546 Free PMC article.

5

Synthesis and structure-activity relationships of antimalarial 4-oxo-3-carboxyl quinolones.

Zhang Y, Guiguemde WA, Sigal M, Zhu F, Connelly MC, Nwaka S, Guy RK. Zhang Y, et al. Among authors: guy rk. Bioorg Med Chem. 2010 Apr 1;18(7):2756-66. doi: 10.1016/j.bmc.2010.02.013. Epub 2010 Feb 11. Bioorg Med Chem. 2010. PMID: 20206533 Free PMC article.

6

Optimization of purine-nitrile TbcatB inhibitors for use in vivo and evaluation of efficacy in murine models.

Mallari JP, Zhu F, Lemoff A, Kaiser M, Lu M, Brun R, Guy RK. Mallari JP, et al. Among authors: guy rk. Bioorg Med Chem. 2010 Dec 1;18(23):8302-9. doi: 10.1016/j.bmc.2010.09.073. Epub 2010 Oct 8. Bioorg Med Chem. 2010. PMID: 21051236

7

Synthesis and evaluation of 7-substituted 4-aminoquinoline analogues for antimalarial activity.

Hwang JY, Kawasuji T, Lowes DJ, Clark JA, Connelly MC, Zhu F, Guiguemde WA, Sigal MS, Wilson EB, Derisi JL, Guy RK. Hwang JY, et al. Among authors: guy rk. J Med Chem. 2011 Oct 27;54(20):7084-93. doi: 10.1021/jm200636z. Epub 2011 Sep 26. J Med Chem. 2011. PMID: 21910466 Free PMC article.

8

Optimization of propafenone analogues as antimalarial leads.

Lowes DJ, Guiguemde WA, Connelly MC, Zhu F, Sigal MS, Clark JA, Lemoff AS, Derisi JL, Wilson EB, Guy RK. Lowes DJ, et al. Among authors: guy rk. J Med Chem. 2011 Nov 10;54(21):7477-85. doi: 10.1021/jm2005546. Epub 2011 Oct 10. J Med Chem. 2011. PMID: 21955244 Free PMC article.

9

Lead optimization of 3-carboxyl-4(1H)-quinolones to deliver orally bioavailable antimalarials.

Zhang Y, Clark JA, Connelly MC, Zhu F, Min J, Guiguemde WA, Pradhan A, Iyer L, Furimsky A, Gow J, Parman T, El Mazouni F, Phillips MA, Kyle DE, Mirsalis J, Guy RK. Zhang Y, et al. Among authors: guy rk. J Med Chem. 2012 May 10;55(9):4205-19. doi: 10.1021/jm201642z. Epub 2012 Apr 18. J Med Chem. 2012. PMID: 22435599 Free PMC article.

10

Lead optimization of antimalarial propafenone analogues.

Lowes D, Pradhan A, Iyer LV, Parman T, Gow J, Zhu F, Furimsky A, Lemoff A, Guiguemde WA, Sigal M, Clark JA, Wilson E, Tang L, Connelly MC, Derisi JL, Kyle DE, Mirsalis J, Guy RK. Lowes D, et al. Among authors: guy rk. J Med Chem. 2012 Jul 12;55(13):6087-93. doi: 10.1021/jm300286a. Epub 2012 Jun 29. J Med Chem. 2012. PMID: 22708838 Free PMC article.

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