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230 results

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Page 1
Pharmacokinetic-Pharmacodynamic Modelling in Hemophilia A: Relating Thrombin and Plasmin Generation to Factor VIII Activity After Administration of a VWF/FVIII Concentrate.
Valke LLFG, Cloesmeijer ME, Mansouritorghabeh H, Barteling W, Blijlevens NMA, Cnossen MH, Mathôt RAA, Schols SEM, van Heerde WL. Valke LLFG, et al. Among authors: mathot raa. Eur J Drug Metab Pharmacokinet. 2024 Mar;49(2):191-205. doi: 10.1007/s13318-024-00876-6. Epub 2024 Feb 17. Eur J Drug Metab Pharmacokinet. 2024. PMID: 38367175 Free PMC article.
Positioning extended half-life concentrates for future use: a practical proposal.
Nederlof A, Mathôt RAA, Leebeek FWG, Fijnvandraat K, Fischer K, Cnossen MH; “OPTI-CLOT” study group. Nederlof A, et al. Among authors: mathot raa. Haemophilia. 2018 Sep;24(5):e369-e372. doi: 10.1111/hae.13588. Epub 2018 Aug 24. Haemophilia. 2018. PMID: 30144218 No abstract available.
Desmopressin treatment combined with clotting factor VIII concentrates in patients with non-severe haemophilia A: protocol for a multicentre single-armed trial, the DAVID study.
Schütte LM, Cnossen MH, van Hest RM, Driessens MHE, Fijnvandraat K, Polinder S, Beckers EAM, Coppens M, Eikenboom J, Laros-van Gorkom BAP, Meijer K, Nieuwenhuizen L, Mauser-Bunschoten EP, Leebeek FWG, Mathôt RAA, Kruip MJHA. Schütte LM, et al. Among authors: mathot raa. BMJ Open. 2019 Apr 23;9(4):e022719. doi: 10.1136/bmjopen-2018-022719. BMJ Open. 2019. PMID: 31015264 Free PMC article.
One piece of the puzzle: Population pharmacokinetics of FVIII during perioperative Haemate P® /Humate P® treatment in von Willebrand disease patients.
de Jager NCB, Bukkems LH, Heijdra JM, Hazendonk CHCAM, Fijnvandraat K, Meijer K, Eikenboom J, Laros-van Gorkom BAP, Leebeek FWG, Cnossen MH, Mathôt RAA; OPTI-CLOT group. de Jager NCB, et al. Among authors: mathot raa. J Thromb Haemost. 2020 Feb;18(2):295-305. doi: 10.1111/jth.14652. Epub 2019 Oct 21. J Thromb Haemost. 2020. PMID: 31557387 Free PMC article.
Optimising the dose of clonidine to achieve sedation in intensive care unit patients with population pharmacokinetics.
Cloesmeijer ME, van den Oever HLA, Mathôt RAA, Zeeman M, Kruisdijk-Gerritsen A, Bles CMA, Nassikovker P, de Meijer AR, van Steveninck FL, Arbouw MEL. Cloesmeijer ME, et al. Among authors: mathot raa. Br J Clin Pharmacol. 2020 Aug;86(8):1620-1631. doi: 10.1111/bcp.14273. Epub 2020 Mar 29. Br J Clin Pharmacol. 2020. PMID: 32150285 Free PMC article.
A Novel, Enriched Population Pharmacokinetic Model for Recombinant Factor VIII-Fc Fusion Protein Concentrate in Hemophilia A Patients.
Bukkems LH, Heijdra JM, Mathias M, Collins PW, Hay CRM, Tait RC, Mangles S, Myers B, Evans G, Bailiff B, Curry N, Payne J, Austin S, Goedhart TMHJ, Leebeek FWG, Meijer K, Fijnvandraat K, Chowdary P, Mathôt RAA, Cnossen MH; for UK-EHL Outcomes Registry OPTI-CLOT Collaboration. Bukkems LH, et al. Among authors: mathot raa. Thromb Haemost. 2020 May;120(5):747-757. doi: 10.1055/s-0040-1709522. Epub 2020 May 5. Thromb Haemost. 2020. PMID: 32369846
von Willebrand Factor and Factor VIII Clearance in Perioperative Hemophilia A Patients.
van Moort I, Bukkems LH, Heijdra JM, Schutgens REG, Laros-van Gorkom BAP, Nieuwenhuizen L, van der Meer FJM, Fijnvandraat K, Ypma P, de Maat MPM, Leebeek FWG, Meijer K, Eikenboom J, Mathôt RAA, Cnossen MH; OPTI-CLOT Study Group. van Moort I, et al. Among authors: mathot raa. Thromb Haemost. 2020 Jul;120(7):1056-1065. doi: 10.1055/s-0040-1710591. Epub 2020 Jun 1. Thromb Haemost. 2020. PMID: 32480417 Clinical Trial.
230 results