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A transient protein folding response targets aggregation in the early phase of TDP-43-mediated neurodegeneration.
San Gil R, Pascovici D, Venturato J, Brown-Wright H, Mehta P, Madrid San Martin L, Wu J, Luan W, Chui YK, Bademosi AT, Swaminathan S, Naidoo S, Berning BA, Wright AL, Keating SS, Curtis MA, Faull RLM, Lee JD, Ngo ST, Lee A, Morsch M, Chung RS, Scotter E, Lisowski L, Mirzaei M, Walker AK. San Gil R, et al. Among authors: morsch m. Nat Commun. 2024 Feb 19;15(1):1508. doi: 10.1038/s41467-024-45646-9. Nat Commun. 2024. PMID: 38374041 Free PMC article.
Muscle specific kinase: organiser of synaptic membrane domains.
Ghazanfari N, Fernandez KJ, Murata Y, Morsch M, Ngo ST, Reddel SW, Noakes PG, Phillips WD. Ghazanfari N, et al. Among authors: morsch m. Int J Biochem Cell Biol. 2011 Mar;43(3):295-8. doi: 10.1016/j.biocel.2010.10.008. Epub 2010 Oct 23. Int J Biochem Cell Biol. 2011. PMID: 20974278 Review.
Expression of ALS/FTD-linked mutant CCNF in zebrafish leads to increased cell death in the spinal cord and an aberrant motor phenotype.
Hogan AL, Don EK, Rayner SL, Lee A, Laird AS, Watchon M, Winnick C, Tarr IS, Morsch M, Fifita JA, Gwee SSL, Formella I, Hortle E, Yuan KC, Molloy MP, Williams KL, Nicholson GA, Chung RS, Blair IP, Cole NJ. Hogan AL, et al. Among authors: morsch m. Hum Mol Genet. 2017 Jul 15;26(14):2616-2626. doi: 10.1093/hmg/ddx136. Hum Mol Genet. 2017. PMID: 28444311
Pathogenic mutation in the ALS/FTD gene, CCNF, causes elevated Lys48-linked ubiquitylation and defective autophagy.
Lee A, Rayner SL, Gwee SSL, De Luca A, Shahheydari H, Sundaramoorthy V, Ragagnin A, Morsch M, Radford R, Galper J, Freckleton S, Shi B, Walker AK, Don EK, Cole NJ, Yang S, Williams KL, Yerbury JJ, Blair IP, Atkin JD, Molloy MP, Chung RS. Lee A, et al. Among authors: morsch m. Cell Mol Life Sci. 2018 Jan;75(2):335-354. doi: 10.1007/s00018-017-2632-8. Epub 2017 Aug 29. Cell Mol Life Sci. 2018. PMID: 28852778 Free PMC article.
70 results