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ATF6 protects against protein misfolding during cardiac hypertrophy.
Hofmann C, Aghajani M, Alcock CD, Blackwood EA, Sandmann C, Herzog N, Groß J, Plate L, Wiseman RL, Kaufman RJ, Katus HA, Jakobi T, Völkers M, Glembotski CC, Doroudgar S. Hofmann C, et al. Among authors: doroudgar s. J Mol Cell Cardiol. 2024 Apr;189:12-24. doi: 10.1016/j.yjmcc.2024.02.001. Epub 2024 Feb 23. J Mol Cell Cardiol. 2024. PMID: 38401179
Saraf-dependent activation of mTORC1 regulates cardiac growth.
Sanlialp A, Schumacher D, Kiper L, Varma E, Riechert E, Ho TC, Hofmann C, Kmietczyk V, Zimmermann F, Dlugosz S, Wirth A, Gorska AA, Burghaus J, Camacho Londoño JE, Katus HA, Doroudgar S, Freichel M, Völkers M. Sanlialp A, et al. Among authors: doroudgar s. J Mol Cell Cardiol. 2020 Apr;141:30-42. doi: 10.1016/j.yjmcc.2020.03.004. Epub 2020 Mar 13. J Mol Cell Cardiol. 2020. PMID: 32173353
Proteomic analysis of the cardiac myocyte secretome reveals extracellular protective functions for the ER stress response.
Blackwood EA, Thuerauf DJ, Stastna M, Stephens H, Sand Z, Pentoney A, Azizi K, Jakobi T, Van Eyk JE, Katus HA, Glembotski CC, Doroudgar S. Blackwood EA, et al. Among authors: doroudgar s. J Mol Cell Cardiol. 2020 Jun;143:132-144. doi: 10.1016/j.yjmcc.2020.04.012. Epub 2020 Apr 25. J Mol Cell Cardiol. 2020. PMID: 32339566 Free PMC article.
S100A4 protects the myocardium against ischemic stress.
Doroudgar S, Quijada P, Konstandin M, Ilves K, Broughton K, Khalafalla FG, Casillas A, Nguyen K, Gude N, Toko H, Ornelas L, Thuerauf DJ, Glembotski CC, Sussman MA, Völkers M. Doroudgar S, et al. J Mol Cell Cardiol. 2016 Nov;100:54-63. doi: 10.1016/j.yjmcc.2016.10.001. Epub 2016 Oct 6. J Mol Cell Cardiol. 2016. PMID: 27721024 Free PMC article.
ATF6 Regulates Cardiac Hypertrophy by Transcriptional Induction of the mTORC1 Activator, Rheb.
Blackwood EA, Hofmann C, Santo Domingo M, Bilal AS, Sarakki A, Stauffer W, Arrieta A, Thuerauf DJ, Kolkhorst FW, Müller OJ, Jakobi T, Dieterich C, Katus HA, Doroudgar S, Glembotski CC. Blackwood EA, et al. Among authors: doroudgar s. Circ Res. 2019 Jan 4;124(1):79-93. doi: 10.1161/CIRCRESAHA.118.313854. Circ Res. 2019. PMID: 30582446 Free PMC article.
Protein Misfolding in Cardiac Disease.
Hofmann C, Katus HA, Doroudgar S. Hofmann C, et al. Among authors: doroudgar s. Circulation. 2019 Apr 30;139(18):2085-2088. doi: 10.1161/CIRCULATIONAHA.118.037417. Circulation. 2019. PMID: 31034286 Review. No abstract available.
mTORC1 inhibition impairs activation of the unfolded protein response and induces cell death during ER stress in cardiomyocytes.
Hofmann C, Löwenthal Z, Aghajani M, Kaufman RJ, Katus HA, Frey N, Glembotski CC, Völkers M, Doroudgar S. Hofmann C, et al. Among authors: doroudgar s. Am J Physiol Heart Circ Physiol. 2023 Aug 1;325(2):H311-H320. doi: 10.1152/ajpheart.00682.2022. Epub 2023 Jun 9. Am J Physiol Heart Circ Physiol. 2023. PMID: 37294892 Free PMC article.
67 results