Wiseman RL - Search Results

1

ATF6 protects against protein misfolding during cardiac hypertrophy.

Hofmann C, Aghajani M, Alcock CD, Blackwood EA, Sandmann C, Herzog N, Groß J, Plate L, Wiseman RL, Kaufman RJ, Katus HA, Jakobi T, Völkers M, Glembotski CC, Doroudgar S. Hofmann C, et al. Among authors: wiseman rl. J Mol Cell Cardiol. 2024 Apr;189:12-24. doi: 10.1016/j.yjmcc.2024.02.001. Epub 2024 Feb 23. J Mol Cell Cardiol. 2024. PMID: 38401179

2

Unfolded protein response activation reduces secretion and extracellular aggregation of amyloidogenic immunoglobulin light chain.

Cooley CB, Ryno LM, Plate L, Morgan GJ, Hulleman JD, Kelly JW, Wiseman RL. Cooley CB, et al. Among authors: wiseman rl. Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13046-51. doi: 10.1073/pnas.1406050111. Epub 2014 Aug 25. Proc Natl Acad Sci U S A. 2014. PMID: 25157167 Free PMC article.

3

Unfolded protein response-induced ERdj3 secretion links ER stress to extracellular proteostasis.

Genereux JC, Qu S, Zhou M, Ryno LM, Wang S, Shoulders MD, Kaufman RJ, Lasmézas CI, Kelly JW, Wiseman RL. Genereux JC, et al. Among authors: wiseman rl. EMBO J. 2015 Jan 2;34(1):4-19. doi: 10.15252/embj.201488896. Epub 2014 Oct 31. EMBO J. 2015. PMID: 25361606 Free PMC article.

4

Modulating protein quality control.

Plate L, Paxman RJ, Wiseman RL, Kelly JW. Plate L, et al. Among authors: wiseman rl. Elife. 2016 Jul 20;5:e18431. doi: 10.7554/eLife.18431. Elife. 2016. PMID: 27435959 Free PMC article.

5

Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation.

Plate L, Cooley CB, Chen JJ, Paxman RJ, Gallagher CM, Madoux F, Genereux JC, Dobbs W, Garza D, Spicer TP, Scampavia L, Brown SJ, Rosen H, Powers ET, Walter P, Hodder P, Wiseman RL, Kelly JW. Plate L, et al. Among authors: wiseman rl. Elife. 2016 Jul 20;5:e15550. doi: 10.7554/eLife.15550. Elife. 2016. PMID: 27435961 Free PMC article.

6

Regulating Secretory Proteostasis through the Unfolded Protein Response: From Function to Therapy.

Plate L, Wiseman RL. Plate L, et al. Among authors: wiseman rl. Trends Cell Biol. 2017 Oct;27(10):722-737. doi: 10.1016/j.tcb.2017.05.006. Epub 2017 Jun 21. Trends Cell Biol. 2017. PMID: 28647092 Free PMC article. Review.

7

The endoplasmic reticulum HSP40 co-chaperone ERdj3/DNAJB11 assembles and functions as a tetramer.

Chen KC, Qu S, Chowdhury S, Noxon IC, Schonhoft JD, Plate L, Powers ET, Kelly JW, Lander GC, Wiseman RL. Chen KC, et al. Among authors: wiseman rl. EMBO J. 2017 Aug 1;36(15):2296-2309. doi: 10.15252/embj.201695616. Epub 2017 Jun 27. EMBO J. 2017. PMID: 28655754 Free PMC article.

8

The unfolded protein response regulator ATF6 promotes mesodermal differentiation.

Kroeger H, Grimsey N, Paxman R, Chiang WC, Plate L, Jones Y, Shaw PX, Trejo J, Tsang SH, Powers E, Kelly JW, Wiseman RL, Lin JH. Kroeger H, et al. Among authors: wiseman rl. Sci Signal. 2018 Feb 13;11(517):eaan5785. doi: 10.1126/scisignal.aan5785. Sci Signal. 2018. PMID: 29440509 Free PMC article.

9

Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins.

Paxman R, Plate L, Blackwood EA, Glembotski C, Powers ET, Wiseman RL, Kelly JW. Paxman R, et al. Among authors: wiseman rl. Elife. 2018 Aug 7;7:e37168. doi: 10.7554/eLife.37168. Elife. 2018. PMID: 30084354 Free PMC article.

10

Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis.

Blackwood EA, Azizi K, Thuerauf DJ, Paxman RJ, Plate L, Kelly JW, Wiseman RL, Glembotski CC. Blackwood EA, et al. Among authors: wiseman rl. Nat Commun. 2019 Jan 14;10(1):187. doi: 10.1038/s41467-018-08129-2. Nat Commun. 2019. PMID: 30643122 Free PMC article.

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