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LGALS3 (galectin 3) mediates an unconventional secretion of SNCA/α-synuclein in response to lysosomal membrane damage by the autophagic-lysosomal pathway in human midbrain dopamine neurons.
Burbidge K, Rademacher DJ, Mattick J, Zack S, Grillini A, Bousset L, Kwon O, Kubicki K, Simon A, Melki R, Campbell EM. Burbidge K, et al. Autophagy. 2022 May;18(5):1020-1048. doi: 10.1080/15548627.2021.1967615. Epub 2021 Oct 6. Autophagy. 2022. PMID: 34612142 Free PMC article.
Benign tumors in TSC are amenable to treatment by GD3 CAR T cells in mice.
Thomas A, Sumughan S, Dellacecca ER, Shivde RS, Lancki N, Mukhatayev Z, Vaca CC, Han F, Barse L, Henning SW, Zamora-Pineda J, Akhtar S, Gupta N, Zahid JO, Zack SR, Ramesh P, Jaishankar D, Lo AS, Moss J, Picken MM, Darling TN, Scholtens DM, Dilling DF, Junghans RP, Le Poole IC. Thomas A, et al. Among authors: zack sr. JCI Insight. 2021 Nov 22;6(22):e152014. doi: 10.1172/jci.insight.152014. JCI Insight. 2021. PMID: 34806651 Free PMC article.
Notch ligands are biomarkers of anti-TNF response in RA patients.
Zack SR, Meyer A, Zanotti B, Volin MV, Deen S, Satoeya N, Sweiss N, Lewis MJ, Pitzalis C, Kitajewski JK, Shahrara S. Zack SR, et al. Angiogenesis. 2024 May;27(2):273-283. doi: 10.1007/s10456-023-09897-2. Epub 2023 Oct 5. Angiogenesis. 2024. PMID: 37796367