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Plitidepsin as an Immunomodulator against Respiratory Viral Infections.
Losada A, Izquierdo-Useros N, Aviles P, Vergara-Alert J, Latino I, Segalés J, Gonzalez SF, Cuevas C, Raïch-Regué D, Muñoz-Alonso MJ, Perez-Zsolt D, Muñoz-Basagoiti J, Rodon J, Chang LA, Warang P, Singh G, Brustolin M, Cantero G, Roca N, Pérez M, Bustos-Morán E, White K, Schotsaert M, García-Sastre A. Losada A, et al. J Immunol. 2024 Apr 15;212(8):1307-1318. doi: 10.4049/jimmunol.2300426. J Immunol. 2024. PMID: 38416036
Unraveling the antiviral activity of plitidepsin against SARS-CoV-2 by subcellular and morphological analysis.
Sachse M, Tenorio R, Fernández de Castro I, Muñoz-Basagoiti J, Perez-Zsolt D, Raïch-Regué D, Rodon J, Losada A, Avilés P, Cuevas C, Paredes R, Segalés J, Clotet B, Vergara-Alert J, Izquierdo-Useros N, Risco C. Sachse M, et al. Among authors: losada a. Antiviral Res. 2022 Apr;200:105270. doi: 10.1016/j.antiviral.2022.105270. Epub 2022 Feb 26. Antiviral Res. 2022. PMID: 35231500 Free PMC article.
Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A.
White KM, Rosales R, Yildiz S, Kehrer T, Miorin L, Moreno E, Jangra S, Uccellini MB, Rathnasinghe R, Coughlan L, Martinez-Romero C, Batra J, Rojc A, Bouhaddou M, Fabius JM, Obernier K, Dejosez M, Guillén MJ, Losada A, Avilés P, Schotsaert M, Zwaka T, Vignuzzi M, Shokat KM, Krogan NJ, García-Sastre A. White KM, et al. Among authors: losada a. Science. 2021 Feb 26;371(6532):926-931. doi: 10.1126/science.abf4058. Epub 2021 Jan 25. Science. 2021. PMID: 33495306 Free PMC article.
The mechanism of action of plitidepsin.
Muñoz-Alonso MJ, González-Santiago L, Martínez T, Losada A, Galmarini CM, Muñoz A. Muñoz-Alonso MJ, et al. Among authors: losada a. Curr Opin Investig Drugs. 2009 Jun;10(6):536-42. Curr Opin Investig Drugs. 2009. PMID: 19513942 Review.
297 results