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Catalytically distinct IDH1 mutants tune phenotype severity in tumor models.
bioRxiv [Preprint]. 2024 Apr 23:2024.04.22.590655. doi: 10.1101/2024.04.22.590655.
bioRxiv. 2024.
PMID: 38712107
Free PMC article.
Preprint.
Active site remodeling in tumor-relevant IDH1 mutants drives distinct kinetic features and potential resistance mechanisms.
Mealka M, Sierra NA, Avellaneda Matteo D, Albekioni E, Khoury R, Mai T, Conley BM, Coleman NJ, Sabo KA, Komives EA, Bobkov AA, Cooksy AL, Silletti S, Schiffer JM, Huxford T, Sohl CD.
Mealka M, et al. Among authors: albekioni e.
Nat Commun. 2024 May 6;15(1):3785. doi: 10.1038/s41467-024-48277-2.
Nat Commun. 2024.
PMID: 38710674
Free PMC article.
Item in Clipboard
Active site remodeling in tumor-relevant IDH1 mutants drives distinct kinetic features and potential resistance mechanisms.
Mealka M, Sierra NA, Matteo DA, Albekioni E, Khoury R, Mai T, Conley BM, Coleman NJ, Sabo KA, Komives EA, Bobkov AA, Cooksy AL, Silletti S, Schiffer JM, Huxford T, Sohl CD.
Mealka M, et al. Among authors: albekioni e.
Res Sq [Preprint]. 2024 Feb 23:rs.3.rs-3889456. doi: 10.21203/rs.3.rs-3889456/v1.
Res Sq. 2024.
PMID: 38464189
Free PMC article.
Updated.
Preprint.
Item in Clipboard
Active site remodeling in tumor-relevant IDH1 mutants drives distinct kinetic features and potential resistance mechanisms.
Mealka M, Sierra NA, Matteo DA, Albekioni E, Khoury R, Mai T, Conley BM, Coleman NJ, Sabo KA, Komives EA, Bobkov AA, Cooksy AL, Silletti S, Schiffer JM, Huxford T, Sohl CD.
Mealka M, et al. Among authors: albekioni e.
bioRxiv [Preprint]. 2024 Jan 23:2024.01.10.574970. doi: 10.1101/2024.01.10.574970.
bioRxiv. 2024.
PMID: 38260668
Free PMC article.
Updated.
Preprint.
Item in Clipboard
Capturing the Dynamic Conformational Changes of Human Isocitrate Dehydrogenase 1 (IDH1) upon Ligand and Metal Binding Using Hydrogen-Deuterium Exchange Mass Spectrometry.
Sabo KA, Albekioni E, Caliger D, Coleman NJ, Thornberg E, Avellaneda Matteo D, Komives EA, Silletti S, Sohl CD.
Sabo KA, et al. Among authors: albekioni e.
Biochemistry. 2023 Mar 21;62(6):1145-1159. doi: 10.1021/acs.biochem.2c00636. Epub 2023 Feb 28.
Biochemistry. 2023.
PMID: 36854124
Free PMC article.
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