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An Enzyme with High Catalytic Proficiency Utilizes Distal Site Substrate Binding Energy to Stabilize the Closed State but at the Expense of Substrate Inhibition.
Robertson AJ, Cruz-Navarrete FA, Wood HP, Vekaria N, Hounslow AM, Bisson C, Cliff MJ, Baxter NJ, Waltho JP. Robertson AJ, et al. Among authors: cruz navarrete fa. ACS Catal. 2022 Mar 4;12(5):3149-3164. doi: 10.1021/acscatal.1c05524. Epub 2022 Feb 22. ACS Catal. 2022. PMID: 35692864 Free PMC article.
Allomorphy as a mechanism of post-translational control of enzyme activity.
Wood HP, Cruz-Navarrete FA, Baxter NJ, Trevitt CR, Robertson AJ, Dix SR, Hounslow AM, Cliff MJ, Waltho JP. Wood HP, et al. Among authors: cruz navarrete fa. Nat Commun. 2020 Nov 2;11(1):5538. doi: 10.1038/s41467-020-19215-9. Nat Commun. 2020. PMID: 33139716 Free PMC article.