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Delivery of a BET protein degrader via a CEACAM6-targeted antibody-drug conjugate inhibits tumour growth in pancreatic cancer models.
Nakazawa Y, Miyano M, Tsukamoto S, Kogai H, Yamamoto A, Iso K, Inoue S, Yamane Y, Yabe Y, Umihara H, Taguchi J, Akagi T, Yamaguchi A, Koga M, Toshimitsu K, Hirayama T, Mukai Y, Machinaga A. Nakazawa Y, et al. Among authors: umihara h. Nat Commun. 2024 Mar 11;15(1):2192. doi: 10.1038/s41467-024-46167-1. Nat Commun. 2024. PMID: 38467634 Free PMC article.
Total Synthesis of (-)-Morphine.
Umihara H, Yokoshima S, Inoue M, Fukuyama T. Umihara H, et al. Chemistry. 2017 May 23;23(29):6993-6995. doi: 10.1002/chem.201701438. Epub 2017 Apr 25. Chemistry. 2017. PMID: 28378531
Antiproliferative Activity of Amathaspiramide Alkaloids and Analogs.
Shimokawa J, Chiyoda K, Umihara H, Fukuyama T. Shimokawa J, et al. Among authors: umihara h. Chem Pharm Bull (Tokyo). 2016 Aug 1;64(8):1239-41. doi: 10.1248/cpb.c16-00256. Epub 2016 May 10. Chem Pharm Bull (Tokyo). 2016. PMID: 27169437 Free article.
Synthesis of (-)-oxycodone.
Kimishima A, Umihara H, Mizoguchi A, Yokoshima S, Fukuyama T. Kimishima A, et al. Among authors: umihara h. Org Lett. 2014 Dec 5;16(23):6244-7. doi: 10.1021/ol503175n. Epub 2014 Nov 25. Org Lett. 2014. PMID: 25423610