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Discovery of Pyridopyrimidinones that Selectively Inhibit the H1047R PI3Kα Mutant Protein.
Ketcham JM, Harwood SJ, Aranda R, Aloiau AN, Bobek BM, Briere DM, Burns AC, Caddell Haatveit K, Calinisan A, Clarine J, Elliott A, Engstrom LD, Gunn RJ, Ivetac A, Jones B, Kuehler J, Lawson JD, Nguyen N, Parker C, Pearson KE, Rahbaek L, Saechao B, Wang X, Waters A, Waters L, Watkins AH, Olson P, Smith CR, Christensen JG, Marx MA. Ketcham JM, et al. Among authors: caddell haatveit k. J Med Chem. 2024 Mar 28;67(6):4936-4949. doi: 10.1021/acs.jmedchem.4c00078. Epub 2024 Mar 13. J Med Chem. 2024. PMID: 38477582 Free PMC article.
A shared mechanistic pathway for pyridoxal phosphate-dependent arginine oxidases.
Hoffarth ER, Caddell Haatveit K, Kuatsjah E, MacNeil GA, Saroya S, Walsby CJ, Eltis LD, Houk KN, Garcia-Borràs M, Ryan KS. Hoffarth ER, et al. Among authors: caddell haatveit k. Proc Natl Acad Sci U S A. 2021 Oct 5;118(40):e2012591118. doi: 10.1073/pnas.2012591118. Proc Natl Acad Sci U S A. 2021. PMID: 34580201 Free PMC article.
Molecular Basis for Spirocycle Formation in the Paraherquamide Biosynthetic Pathway.
Fraley AE, Caddell Haatveit K, Ye Y, Kelly SP, Newmister SA, Yu F, Williams RM, Smith JL, Houk KN, Sherman DH. Fraley AE, et al. Among authors: caddell haatveit k. J Am Chem Soc. 2020 Feb 5;142(5):2244-2252. doi: 10.1021/jacs.9b09070. Epub 2020 Jan 16. J Am Chem Soc. 2020. PMID: 31904957 Free PMC article.