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Clinical validation of the PrecivityAD2 blood test: A mass spectrometry-based test with algorithm combining %p-tau217 and Aβ42/40 ratio to identify presence of brain amyloid.
Meyer MR, Kirmess KM, Eastwood S, Wente-Roth TL, Irvin F, Holubasch MS, Venkatesh V, Fogelman I, Monane M, Hanna L, Rabinovici GD, Siegel BA, Whitmer RA, Apgar C, Bateman RJ, Holtzman DM, Irizarry M, Verbel D, Sachdev P, Ito S, Contois J, Yarasheski KE, Braunstein JB, Verghese PB, West T. Meyer MR, et al. Among authors: holtzman dm. Alzheimers Dement. 2024 May;20(5):3179-3192. doi: 10.1002/alz.13764. Epub 2024 Mar 16. Alzheimers Dement. 2024. PMID: 38491912 Free PMC article.
KATP channels are necessary for glucose-dependent increases in amyloid-β and Alzheimer's disease-related pathology.
Grizzanti J, Moritz WR, Pait MC, Stanley M, Kaye SD, Carroll CM, Constantino NJ, Deitelzweig LJ, Snipes JA, Kellar D, Caesar EE, Pettit-Mee RJ, Day SM, Sens JP, Nicol NI, Dhillon J, Remedi MS, Kiraly DD, Karch CM, Nichols CG, Holtzman DM, Macauley SL. Grizzanti J, et al. Among authors: holtzman dm. JCI Insight. 2023 May 2;8(10):e162454. doi: 10.1172/jci.insight.162454. JCI Insight. 2023. PMID: 37129980 Free PMC article.
APOE2 gene therapy reduces amyloid deposition and improves markers of neuroinflammation and neurodegeneration in a mouse model of Alzheimer disease.
Jackson RJ, Keiser MS, Meltzer JC, Fykstra DP, Dierksmeier SE, Hajizadeh S, Kreuzer J, Morris R, Melloni A, Nakajima T, Tecedor L, Ranum PT, Carrell E, Chen Y, Nishtar MA, Holtzman DM, Haas W, Davidson BL, Hyman BT. Jackson RJ, et al. Among authors: holtzman dm. Mol Ther. 2024 May 1;32(5):1373-1386. doi: 10.1016/j.ymthe.2024.03.024. Epub 2024 Mar 19. Mol Ther. 2024. PMID: 38504517 Free article.
APOE3ch alters microglial response and suppresses Aβ-induced tau seeding and spread.
Chen Y, Song S, Parhizkar S, Lord J, Zhu Y, Strickland MR, Wang C, Park J, Tabor GT, Jiang H, Li K, Davis AA, Yuede CM, Colonna M, Ulrich JD, Holtzman DM. Chen Y, et al. Among authors: holtzman dm. Cell. 2024 Jan 18;187(2):428-445.e20. doi: 10.1016/j.cell.2023.11.029. Epub 2023 Dec 11. Cell. 2024. PMID: 38086389
612 results