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Soluble ACE2 correlates with severe COVID-19 and can impair antibody responses.
Lebedin M, Ratswohl C, Garg A, Schips M, García CV, Spatt L, Thibeault C, Obermayer B, Weiner J, Velásquez IM, Gerhard C, Stubbemann P, Hanitsch LG, Pischon T, Witzenrath M, Sander LE, Kurth F, Meyer-Hermann M, de la Rosa K. Lebedin M, et al. Among authors: hanitsch lg. iScience. 2024 Feb 24;27(3):109330. doi: 10.1016/j.isci.2024.109330. eCollection 2024 Mar 15. iScience. 2024. PMID: 38496296 Free PMC article.
Disease Severity, Fever, Age, and Sex Correlate With SARS-CoV-2 Neutralizing Antibody Responses.
Schlickeiser S, Schwarz T, Steiner S, Wittke K, Al Besher N, Meyer O, Kalus U, Pruß A, Kurth F, Zoller T, Witzenrath M, Sander LE, Müller MA, Scheibenbogen C, Volk HD, Drosten C, Corman VM, Hanitsch LG. Schlickeiser S, et al. Among authors: hanitsch lg. Front Immunol. 2021 Jan 29;11:628971. doi: 10.3389/fimmu.2020.628971. eCollection 2020. Front Immunol. 2021. PMID: 33584731 Free PMC article.
CD169/SIGLEC1 is expressed on circulating monocytes in COVID-19 and expression levels are associated with disease severity.
Doehn JM, Tabeling C, Biesen R, Saccomanno J, Madlung E, Pappe E, Gabriel F, Kurth F, Meisel C, Corman VM, Hanitsch LG, Treskatsch S, Heim K, Stegemann MS, Ruwwe-Glösenkamp C, Müller-Redetzky HC, Uhrig A, Somasundaram R, Spies C, von Bernuth H, Hofmann J, Drosten C, Suttorp N, Witzenrath M, Sander LE, Hübner RH. Doehn JM, et al. Among authors: hanitsch lg. Infection. 2021 Aug;49(4):757-762. doi: 10.1007/s15010-021-01606-9. Epub 2021 Apr 6. Infection. 2021. PMID: 33825125 Free PMC article.
Untimely TGFβ responses in COVID-19 limit antiviral functions of NK cells.
Witkowski M, Tizian C, Ferreira-Gomes M, Niemeyer D, Jones TC, Heinrich F, Frischbutter S, Angermair S, Hohnstein T, Mattiola I, Nawrath P, McEwen S, Zocche S, Viviano E, Heinz GA, Maurer M, Kölsch U, Chua RL, Aschman T, Meisel C, Radke J, Sawitzki B, Roehmel J, Allers K, Moos V, Schneider T, Hanitsch L, Mall MA, Conrad C, Radbruch H, Duerr CU, Trapani JA, Marcenaro E, Kallinich T, Corman VM, Kurth F, Sander LE, Drosten C, Treskatsch S, Durek P, Kruglov A, Radbruch A, Mashreghi MF, Diefenbach A. Witkowski M, et al. Nature. 2021 Dec;600(7888):295-301. doi: 10.1038/s41586-021-04142-6. Epub 2021 Oct 25. Nature. 2021. PMID: 34695836
SARS-CoV-2 T Cell Response in Severe and Fatal COVID-19 in Primary Antibody Deficiency Patients Without Specific Humoral Immunity.
Steiner S, Schwarz T, Corman VM, Gebert L, Kleinschmidt MC, Wald A, Gläser S, Kruse JM, Zickler D, Peric A, Meisel C, Meyer T, Staudacher OL, Wittke K, Kedor C, Bauer S, Besher NA, Kalus U, Pruß A, Drosten C, Volk HD, Scheibenbogen C, Hanitsch LG. Steiner S, et al. Among authors: hanitsch lg. Front Immunol. 2022 Mar 10;13:840126. doi: 10.3389/fimmu.2022.840126. eCollection 2022. Front Immunol. 2022. PMID: 35359967 Free PMC article.
SARS-CoV-2 variant Alpha has a spike-dependent replication advantage over the ancestral B.1 strain in human cells with low ACE2 expression.
Niemeyer D, Stenzel S, Veith T, Schroeder S, Friedmann K, Weege F, Trimpert J, Heinze J, Richter A, Jansen J, Emanuel J, Kazmierski J, Pott F, Jeworowski LM, Olmer R, Jaboreck MC, Tenner B, Papies J, Walper F, Schmidt ML, Heinemann N, Möncke-Buchner E, Baumgardt M, Hoffmann K, Widera M, Thao TTN, Balázs A, Schulze J, Mache C, Jones TC, Morkel M, Ciesek S, Hanitsch LG, Mall MA, Hocke AC, Thiel V, Osterrieder K, Wolff T, Martin U, Corman VM, Müller MA, Goffinet C, Drosten C. Niemeyer D, et al. Among authors: hanitsch lg. PLoS Biol. 2022 Nov 16;20(11):e3001871. doi: 10.1371/journal.pbio.3001871. eCollection 2022 Nov. PLoS Biol. 2022. PMID: 36383605 Free PMC article.
A prospective observational study of post-COVID-19 chronic fatigue syndrome following the first pandemic wave in Germany and biomarkers associated with symptom severity.
Kedor C, Freitag H, Meyer-Arndt L, Wittke K, Hanitsch LG, Zoller T, Steinbeis F, Haffke M, Rudolf G, Heidecker B, Bobbert T, Spranger J, Volk HD, Skurk C, Konietschke F, Paul F, Behrends U, Bellmann-Strobl J, Scheibenbogen C. Kedor C, et al. Among authors: hanitsch lg. Nat Commun. 2022 Aug 30;13(1):5104. doi: 10.1038/s41467-022-32507-6. Nat Commun. 2022. PMID: 36042189 Free PMC article.
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