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SARS-CoV-2 desensitizes host cells to interferon through inhibition of the JAK-STAT pathway.
Chen DY, Khan N, Close BJ, Goel RK, Blum B, Tavares AH, Kenney D, Conway HL, Ewoldt JK, Kapell S, Chitalia VC, Crossland NA, Chen CS, Kotton DN, Baker SC, Connor JH, Douam F, Emili A, Saeed M. Chen DY, et al. Among authors: kenney d. bioRxiv [Preprint]. 2020 Oct 28:2020.10.27.358259. doi: 10.1101/2020.10.27.358259. bioRxiv. 2020. PMID: 33140044 Free PMC article. Preprint.
Fatal neuroinvasion and SARS-CoV-2 tropism in K18-hACE2 mice is partially independent on hACE2 expression.
Carossino M, Montanaro P, O'Connell A, Kenney D, Gertje H, Grosz K, Ericsson M, Huber BR, Subramaniam S, Kirkland TA, Walker JR, Francis KP, Klose AD, Paragas N, Kurnick S, Bosmann M, Saeed M, Balasuriya U, Douam F, Crossland N. Carossino M, et al. Among authors: kenney d. bioRxiv [Preprint]. 2021 Sep 23:2021.01.13.425144. doi: 10.1101/2021.01.13.425144. bioRxiv. 2021. PMID: 33469581 Free PMC article. Updated. Preprint.
SARS-CoV-2 Disrupts Proximal Elements in the JAK-STAT Pathway.
Chen DY, Khan N, Close BJ, Goel RK, Blum B, Tavares AH, Kenney D, Conway HL, Ewoldt JK, Chitalia VC, Crossland NA, Chen CS, Kotton DN, Baker SC, Fuchs SY, Connor JH, Douam F, Emili A, Saeed M. Chen DY, et al. Among authors: kenney d. J Virol. 2021 Sep 9;95(19):e0086221. doi: 10.1128/JVI.00862-21. Epub 2021 Sep 9. J Virol. 2021. PMID: 34260266 Free PMC article.
Fatal Neurodissemination and SARS-CoV-2 Tropism in K18-hACE2 Mice Is Only Partially Dependent on hACE2 Expression.
Carossino M, Kenney D, O'Connell AK, Montanaro P, Tseng AE, Gertje HP, Grosz KA, Ericsson M, Huber BR, Kurnick SA, Subramaniam S, Kirkland TA, Walker JR, Francis KP, Klose AD, Paragas N, Bosmann M, Saeed M, Balasuriya UBR, Douam F, Crossland NA. Carossino M, et al. Among authors: kenney d. Viruses. 2022 Mar 5;14(3):535. doi: 10.3390/v14030535. Viruses. 2022. PMID: 35336942 Free PMC article.
Humanized mice reveal a macrophage-enriched gene signature defining human lung tissue protection during SARS-CoV-2 infection.
Kenney DJ, O'Connell AK, Turcinovic J, Montanaro P, Hekman RM, Tamura T, Berneshawi AR, Cafiero TR, Al Abdullatif S, Blum B, Goldstein SI, Heller BL, Gertje HP, Bullitt E, Trachtenberg AJ, Chavez E, Nono ET, Morrison C, Tseng AE, Sheikh A, Kurnick S, Grosz K, Bosmann M, Ericsson M, Huber BR, Saeed M, Balazs AB, Francis KP, Klose A, Paragas N, Campbell JD, Connor JH, Emili A, Crossland NA, Ploss A, Douam F. Kenney DJ, et al. Cell Rep. 2022 Apr 19;39(3):110714. doi: 10.1016/j.celrep.2022.110714. Epub 2022 Apr 4. Cell Rep. 2022. PMID: 35421379 Free PMC article.
Role of spike in the pathogenic and antigenic behavior of SARS-CoV-2 BA.1 Omicron.
Chen DY, Kenney D, Chin CV, Tavares AH, Khan N, Conway HL, Liu G, Choudhary MC, Gertje HP, O'Connell AK, Kotton DN, Herrmann A, Ensser A, Connor JH, Bosmann M, Li JZ, Gack MU, Baker SC, Kirchdoerfer RN, Kataria Y, Crossland NA, Douam F, Saeed M. Chen DY, et al. Among authors: kenney d. bioRxiv [Preprint]. 2023 Jan 10:2022.10.13.512134. doi: 10.1101/2022.10.13.512134. bioRxiv. 2023. PMID: 36263066 Free PMC article. Preprint.
Spike and nsp6 are key determinants of SARS-CoV-2 Omicron BA.1 attenuation.
Chen DY, Chin CV, Kenney D, Tavares AH, Khan N, Conway HL, Liu G, Choudhary MC, Gertje HP, O'Connell AK, Adams S, Kotton DN, Herrmann A, Ensser A, Connor JH, Bosmann M, Li JZ, Gack MU, Baker SC, Kirchdoerfer RN, Kataria Y, Crossland NA, Douam F, Saeed M. Chen DY, et al. Among authors: kenney d. Nature. 2023 Mar;615(7950):143-150. doi: 10.1038/s41586-023-05697-2. Epub 2023 Jan 11. Nature. 2023. PMID: 36630998
166 results