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Page 1
Apelin stimulation of the vascular skeletal muscle stem cell niche enhances endogenous repair in dystrophic mice.
Le Moal E, Liu Y, Collerette-Tremblay J, Dumontier S, Fabre P, Molina T, Dort J, Orfi Z, Denault N, Boutin J, Michaud J, Giguère H, Desroches A, Trân K, Ellezam B, Vézina F, Bedard S, Raynaud C, Balg F, Sarret P, Boudreault PL, Scott MS, Denault JB, Marsault E, Feige JN, Auger-Messier M, Dumont NA, Bentzinger CF. Le Moal E, et al. Among authors: boudreault pl. Sci Transl Med. 2024 Mar 20;16(739):eabn8529. doi: 10.1126/scitranslmed.abn8529. Epub 2024 Mar 20. Sci Transl Med. 2024. PMID: 38507466
Modulating the selectivity of matriptase-2 inhibitors with unnatural amino acids.
St-Georges C, Désilets A, Béliveau F, Ghinet M, Dion SP, Colombo É, Boudreault PL, Najmanovich RJ, Leduc R, Marsault É. St-Georges C, et al. Among authors: boudreault pl. Eur J Med Chem. 2017 Mar 31;129:110-123. doi: 10.1016/j.ejmech.2017.02.006. Epub 2017 Feb 11. Eur J Med Chem. 2017. PMID: 28219045
Modulation of the Passive Permeability of Semipeptidic Macrocycles: N- and C-Methylations Fine-Tune Conformation and Properties.
Comeau C, Ries B, Stadelmann T, Tremblay J, Poulet S, Fröhlich U, Côté J, Boudreault PL, Derbali RM, Sarret P, Grandbois M, Leclair G, Riniker S, Marsault É. Comeau C, et al. Among authors: boudreault pl. J Med Chem. 2021 May 13;64(9):5365-5383. doi: 10.1021/acs.jmedchem.0c02036. Epub 2021 Mar 22. J Med Chem. 2021. PMID: 33750117
Pharmacodynamic and pharmacokinetic profiles of a neurotensin receptor type 2 (NTS2) analgesic macrocyclic analog.
Chartier M, Desgagné M, Sousbie M, Rumsby C, Chevillard L, Théroux L, Haroune L, Côté J, Longpré JM, Boudreault PL, Marsault É, Sarret P. Chartier M, et al. Among authors: boudreault pl. Biomed Pharmacother. 2021 Sep;141:111861. doi: 10.1016/j.biopha.2021.111861. Epub 2021 Jul 3. Biomed Pharmacother. 2021. PMID: 34229249 Free article.
Size-Reduced Macrocyclic Analogues of [Pyr1]-apelin-13 Showing Negative Gα12 Bias Still Produce Prolonged Cardiac Effects.
Tran K, Sainsily X, Côté J, Coquerel D, Couvineau P, Saibi S, Haroune L, Besserer-Offroy É, Flynn-Robitaille J, Resua Rojas M, Murza A, Longpré JM, Auger-Messier M, Lesur O, Bouvier M, Marsault É, Boudreault PL, Sarret P. Tran K, et al. Among authors: boudreault pl. J Med Chem. 2022 Jan 13;65(1):531-551. doi: 10.1021/acs.jmedchem.1c01708. Epub 2022 Jan 4. J Med Chem. 2022. PMID: 34982553
Signaling Modulation via Minimal C-Terminal Modifications of Apelin-13.
Théroux L, Van Den Hauwe R, Trân K, Fournier J, Desgagné M, Meneboo N, Lavallée A, Fröhlich U, Côté J, Hollanders C, Longpré JM, Murza A, Marsault E, Sarret P, Boudreault PL, Ballet S. Théroux L, et al. Among authors: boudreault pl. ACS Pharmacol Transl Sci. 2023 Jan 26;6(2):290-305. doi: 10.1021/acsptsci.2c00219. eCollection 2023 Feb 10. ACS Pharmacol Transl Sci. 2023. PMID: 36798478 Free PMC article.
Beyond Rule-of-five: Permeability Assessment of Semipeptidic Macrocycles.
L'Exact M, Comeau C, Bourhis A, Boisvert O, Fröhlich U, Létourneau D, Marsault É, Lavigne P, Grandbois M, Boudreault PL. L'Exact M, et al. Among authors: boudreault pl. Biochim Biophys Acta Biomembr. 2023 Oct;1865(7):184196. doi: 10.1016/j.bbamem.2023.184196. Epub 2023 Jul 1. Biochim Biophys Acta Biomembr. 2023. PMID: 37400050
49 results