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Cell subtype-specific effects of genetic variation in the Alzheimer's disease brain.
Fujita M, Gao Z, Zeng L, McCabe C, White CC, Ng B, Green GS, Rozenblatt-Rosen O, Phillips D, Amir-Zilberstein L, Lee H, Pearse RV 2nd, Khan A, Vardarajan BN, Kiryluk K, Ye CJ, Klein HU, Wang G, Regev A, Habib N, Schneider JA, Wang Y, Young-Pearse T, Mostafavi S, Bennett DA, Menon V, De Jager PL. Fujita M, et al. Among authors: young pearse t. Nat Genet. 2024 Apr;56(4):605-614. doi: 10.1038/s41588-024-01685-y. Epub 2024 Mar 21. Nat Genet. 2024. PMID: 38514782
Person-specific differences in ubiquitin-proteasome mediated proteostasis in human neurons.
Hsieh YC, Augur ZM, Arbery M, Ashour N, Barrett K, Pearse RV 2nd, Tio ES, Duong DM, Felsky D, De Jager PL, Bennett DA, Seyfried NT, Young-Pearse TL. Hsieh YC, et al. Among authors: young pearse tl. Alzheimers Dement. 2024 Apr;20(4):2952-2967. doi: 10.1002/alz.13680. Epub 2024 Mar 12. Alzheimers Dement. 2024. PMID: 38470006 Free PMC article.
ZCCHC17 Modulates Neuronal RNA Splicing and Supports Cognitive Resilience in Alzheimer's Disease.
Bartosch AMW, Youth EHH, Hansen S, Wu Y, Buchanan HM, Kaufman ME, Xiao H, Koo SY, Ashok A, Sivakumar S, Soni RK, Dumitrescu LC, Lam TG, Ropri AS, Lee AJ, Klein HU, Vardarajan BN, Bennett DA, Young-Pearse TL, De Jager PL, Hohman TJ, Sproul AA, Teich AF. Bartosch AMW, et al. Among authors: young pearse tl. J Neurosci. 2024 Jan 17;44(3):e2324222023. doi: 10.1523/JNEUROSCI.2324-22.2023. J Neurosci. 2024. PMID: 38050142
INPP5D regulates inflammasome activation in human microglia.
Chou V, Pearse RV 2nd, Aylward AJ, Ashour N, Taga M, Terzioglu G, Fujita M, Fancher SB, Sigalov A, Benoit CR, Lee H, Lam M, Seyfried NT, Bennett DA, De Jager PL, Menon V, Young-Pearse TL. Chou V, et al. Among authors: young pearse tl. Nat Commun. 2023 Nov 29;14(1):7552. doi: 10.1038/s41467-023-42819-w. Nat Commun. 2023. PMID: 38016942 Free PMC article.
Cell-type-specific regulation of APOE and CLU levels in human neurons by the Alzheimer's disease risk gene SORL1.
Lee H, Aylward AJ, Pearse RV 2nd, Lish AM, Hsieh YC, Augur ZM, Benoit CR, Chou V, Knupp A, Pan C, Goberdhan S, Duong DM, Seyfried NT, Bennett DA, Taga MF, Huynh K, Arnold M, Meikle PJ, De Jager PL, Menon V, Young JE, Young-Pearse TL. Lee H, et al. Among authors: young pearse tl. Cell Rep. 2023 Aug 29;42(8):112994. doi: 10.1016/j.celrep.2023.112994. Epub 2023 Aug 22. Cell Rep. 2023. PMID: 37611586 Free PMC article.
3D bioengineered neural tissue generated from patient-derived iPSCs mimics time-dependent phenotypes and transcriptional features of Alzheimer's disease.
Lomoio S, Pandey RS, Rouleau N, Menicacci B, Kim W, Cantley WL, Haydon PG, Bennett DA, Young-Pearse TL, Carter GW, Kaplan DL, Tesco G. Lomoio S, et al. Among authors: young pearse tl. Mol Psychiatry. 2023 Dec;28(12):5390-5401. doi: 10.1038/s41380-023-02147-3. Epub 2023 Jun 26. Mol Psychiatry. 2023. PMID: 37365240
69 results