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Convergent evolution and targeting of diverse E2 epitopes by human broadly neutralizing antibodies are associated with HCV clearance.
Ogega CO, Skinner NE, Schoenle MV, Wilcox XE, Frumento N, Wright DA, Paul HT, Sinnis-Bourozikas A, Clark KE, Figueroa A, Bjorkman PJ, Ray SC, Flyak AI, Bailey JR. Ogega CO, et al. Among authors: flyak ai. Immunity. 2024 Apr 9;57(4):890-903.e6. doi: 10.1016/j.immuni.2024.03.001. Epub 2024 Mar 21. Immunity. 2024. PMID: 38518779
Computational identification of HCV neutralizing antibodies with a common HCDR3 disulfide bond motif in the antibody repertoires of infected individuals.
Bozhanova NG, Flyak AI, Brown BP, Ruiz SE, Salas J, Rho S, Bombardi RG, Myers L, Soto C, Bailey JR, Crowe JE Jr, Bjorkman PJ, Meiler J. Bozhanova NG, et al. Among authors: flyak ai. Nat Commun. 2022 Jun 8;13(1):3178. doi: 10.1038/s41467-022-30865-9. Nat Commun. 2022. PMID: 35676279 Free PMC article. Review.
Analysis of antibodies from HCV elite neutralizers identifies genetic determinants of broad neutralization.
Weber T, Potthoff J, Bizu S, Labuhn M, Dold L, Schoofs T, Horning M, Ercanoglu MS, Kreer C, Gieselmann L, Vanshylla K, Langhans B, Janicki H, Ströh LJ, Knops E, Nierhoff D, Spengler U, Kaiser R, Bjorkman PJ, Krey T, Bankwitz D, Pfeifer N, Pietschmann T, Flyak AI, Klein F. Weber T, et al. Among authors: flyak ai. Immunity. 2022 Feb 8;55(2):341-354.e7. doi: 10.1016/j.immuni.2021.12.003. Epub 2022 Jan 5. Immunity. 2022. PMID: 34990590 Free PMC article.
Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations.
Muecksch F, Weisblum Y, Barnes CO, Schmidt F, Schaefer-Babajew D, Wang Z, C Lorenzi JC, Flyak AI, DeLaitsch AT, Huey-Tubman KE, Hou S, Schiffer CA, Gaebler C, Da Silva J, Poston D, Finkin S, Cho A, Cipolla M, Oliveira TY, Millard KG, Ramos V, Gazumyan A, Rutkowska M, Caskey M, Nussenzweig MC, Bjorkman PJ, Hatziioannou T, Bieniasz PD. Muecksch F, et al. Among authors: flyak ai. Immunity. 2021 Aug 10;54(8):1853-1868.e7. doi: 10.1016/j.immuni.2021.07.008. Epub 2021 Jul 30. Immunity. 2021. PMID: 34331873 Free PMC article.
Mechanisms of HCV resistance to broadly neutralizing antibodies.
Frumento N, Flyak AI, Bailey JR. Frumento N, et al. Among authors: flyak ai. Curr Opin Virol. 2021 Oct;50:23-29. doi: 10.1016/j.coviro.2021.07.003. Epub 2021 Jul 28. Curr Opin Virol. 2021. PMID: 34329953 Free PMC article. Review.
Development of potency, breadth and resilience to viral escape mutations in SARS-CoV-2 neutralizing antibodies.
Muecksch F, Weisblum Y, Barnes CO, Schmidt F, Schaefer-Babajew D, Lorenzi JCC, Flyak AI, DeLaitsch AT, Huey-Tubman KE, Hou S, Schiffer CA, Gaebler C, Wang Z, Da Silva J, Poston D, Finkin S, Cho A, Cipolla M, Oliveira TY, Millard KG, Ramos V, Gazumyan A, Rutkowska M, Caskey M, Nussenzweig MC, Bjorkman PJ, Hatziioannou T, Bieniasz PD. Muecksch F, et al. Among authors: flyak ai. bioRxiv [Preprint]. 2021 Mar 8:2021.03.07.434227. doi: 10.1101/2021.03.07.434227. bioRxiv. 2021. PMID: 33758864 Free PMC article. Updated. Preprint.
37 results