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Cancer cell genetics shaping of the tumor microenvironment reveals myeloid cell-centric exploitable vulnerabilities in hepatocellular carcinoma.
Nat Commun. 2024 Mar 22;15(1):2581. doi: 10.1038/s41467-024-46835-2.
Nat Commun. 2024.
PMID: 38519484
Free PMC article.
Multiparametric Analyses of Hepatocellular Carcinoma Somatic Mouse Models and Their Associated Tumor Microenvironment.
Taranto D, Ramirez CFA, Vegna S, de Groot MHP, de Wit N, Van Baalen M, Klarenbeek S, Akkari L.
Taranto D, et al. Among authors: de groot mhp.
Curr Protoc. 2021 Jun;1(6):e147. doi: 10.1002/cpz1.147.
Curr Protoc. 2021.
PMID: 34101385
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EGFR activation limits the response of liver cancer to lenvatinib.
Jin H, Shi Y, Lv Y, Yuan S, Ramirez CFA, Lieftink C, Wang L, Wang S, Wang C, Dias MH, Jochems F, Yang Y, Bosma A, Hijmans EM, de Groot MHP, Vegna S, Cui D, Zhou Y, Ling J, Wang H, Guo Y, Zheng X, Isima N, Wu H, Sun C, Beijersbergen RL, Akkari L, Zhou W, Zhai B, Qin W, Bernards R.
Jin H, et al. Among authors: de groot mhp.
Nature. 2021 Jul;595(7869):730-734. doi: 10.1038/s41586-021-03741-7. Epub 2021 Jul 21.
Nature. 2021.
PMID: 34290403
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Rational combination of SHP2 and mTOR inhibition for the treatment of hepatocellular carcinoma.
Mulero-Sánchez A, Ramirez CFA, du Chatinier A, Wang H, Koomen SJI, Song JY, de Groot MHP, Lieftink C, Bosma A, Burylo A, van Tellingen O, Beijersbergen RL, Wang C, Akkari L, Bernards R, Mainardi S.
Mulero-Sánchez A, et al. Among authors: de groot mhp.
Mol Oncol. 2023 Jun;17(6):964-980. doi: 10.1002/1878-0261.13377. Epub 2023 Feb 9.
Mol Oncol. 2023.
PMID: 36650715
Free PMC article.
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CD103+ regulatory T cells underlie resistance to radio-immunotherapy and impair CD8+ T cell activation in glioblastoma.
van Hooren L, Handgraaf SM, Kloosterman DJ, Karimi E, van Mil LWHG, Gassama AA, Solsona BG, de Groot MHP, Brandsma D, Quail DF, Walsh LA, Borst GR, Akkari L.
van Hooren L, et al. Among authors: de groot mhp.
Nat Cancer. 2023 May;4(5):665-681. doi: 10.1038/s43018-023-00547-6. Epub 2023 Apr 20.
Nat Cancer. 2023.
PMID: 37081259
Free PMC article.
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Dynamic changes in glioma macrophage populations after radiotherapy reveal CSF-1R inhibition as a strategy to overcome resistance.
Akkari L, Bowman RL, Tessier J, Klemm F, Handgraaf SM, de Groot M, Quail DF, Tillard L, Gadiot J, Huse JT, Brandsma D, Westerga J, Watts C, Joyce JA.
Akkari L, et al.
Sci Transl Med. 2020 Jul 15;12(552):eaaw7843. doi: 10.1126/scitranslmed.aaw7843.
Sci Transl Med. 2020.
PMID: 32669424
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Experimental Simulation of the Effects of an Initial Antibiotic Treatment on a Subsequent Treatment after Initial Therapy Failure.
Feng Y, Händel N, de Groot MH, Brul S, Schultsz C, Ter Kuile BH.
Feng Y, et al.
Antibiotics (Basel). 2014 Feb 17;3(1):49-63. doi: 10.3390/antibiotics3010049.
Antibiotics (Basel). 2014.
PMID: 27025733
Free PMC article.
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