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Mtb-Selective 5-Aminomethyl Oxazolidinone Prodrugs: Robust Potency and Potential Liabilities.
ACS Infect Dis. 2024 May 10;10(5):1679-1695. doi: 10.1021/acsinfecdis.4c00025. Epub 2024 Apr 6.
ACS Infect Dis. 2024.
PMID: 38581700
Normalizing granuloma vasculature and matrix improves drug delivery and reduces bacterial burden in tuberculosis-infected rabbits.
Datta M, Via LE, Dartois V, Weiner DM, Zimmerman M, Kaya F, Walker AM, Fleegle JD, Raplee ID, McNinch C, Zarodniuk M, Kamoun WS, Yue C, Kumar AS, Subudhi S, Xu L, Barry CE 3rd, Jain RK.
Datta M, et al. Among authors: fleegle jd.
Proc Natl Acad Sci U S A. 2024 Apr 2;121(14):e2321336121. doi: 10.1073/pnas.2321336121. Epub 2024 Mar 26.
Proc Natl Acad Sci U S A. 2024.
PMID: 38530888
Free PMC article.
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IL-10 suppresses T cell expansion while promoting tissue-resident memory cell formation during SARS-CoV-2 infection in rhesus macaques.
Nelson CE, Foreman TW, Kauffman KD, Sakai S, Gould ST, Fleegle JD, Gomez F; NIAID/DIR Tuberculosis Imaging Program; Le Nouën C, Liu X, Burdette TL, Garza NL, Lafont BAP, Brooks K, Arlehamn CSL, Weiskopf D, Sette A, Hickman HD, Buchholz UJ, Johnson RF, Brenchley JM, Via LE, Barber DL.
Nelson CE, et al. Among authors: fleegle jd.
bioRxiv [Preprint]. 2022 Sep 15:2022.09.13.507852. doi: 10.1101/2022.09.13.507852.
bioRxiv. 2022.
PMID: 36172119
Free PMC article.
Preprint.
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CD4 T cells are rapidly depleted from tuberculosis granulomas following acute SIV co-infection.
Foreman TW, Nelson CE, Kauffman KD, Lora NE, Vinhaes CL, Dorosky DE, Sakai S, Gomez F, Fleegle JD, Parham M, Perera SR, Lindestam Arlehamn CS, Sette A; Tuberculosis Imaging Program; Brenchley JM, Queiroz ATL, Andrade BB, Kabat J, Via LE, Barber DL.
Foreman TW, et al. Among authors: fleegle jd.
Cell Rep. 2022 May 31;39(9):110896. doi: 10.1016/j.celrep.2022.110896.
Cell Rep. 2022.
PMID: 35649361
Free article.
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Mild SARS-CoV-2 infection in rhesus macaques is associated with viral control prior to antigen-specific T cell responses in tissues.
Nelson CE, Namasivayam S, Foreman TW, Kauffman KD, Sakai S, Dorosky DE, Lora NE; NIAID/DIR Tuberculosis Imaging Program; Brooks K, Potter EL, Garza NL, Lafont BAP, Johnson RF, Roederer M, Sher A, Weiskopf D, Sette A, de Wit E, Hickman HD, Brenchley JM, Via LE, Barber DL.
Nelson CE, et al.
Sci Immunol. 2022 Mar 10:eabo0535. doi: 10.1126/sciimmunol.abo0535. Online ahead of print.
Sci Immunol. 2022.
PMID: 35271298
Free PMC article.
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Functional inactivation of pulmonary MAIT cells following 5-OP-RU treatment of non-human primates.
Sakai S, Lora NE, Kauffman KD, Dorosky DE, Oh S, Namasivayam S, Gomez F, Fleegle JD; Tuberculosis Imaging Program; Arlehamn CSL, Sette A, Sher A, Freeman GJ, Via LE, Barry Iii CE, Barber DL.
Sakai S, et al. Among authors: fleegle jd.
Mucosal Immunol. 2021 Sep;14(5):1055-1066. doi: 10.1038/s41385-021-00425-3. Epub 2021 Jun 22.
Mucosal Immunol. 2021.
PMID: 34158594
Free PMC article.
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