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Anti-tau antibody administration increases plasma tau in transgenic mice and patients with tauopathy.
Yanamandra K, Patel TK, Jiang H, Schindler S, Ulrich JD, Boxer AL, Miller BL, Kerwin DR, Gallardo G, Stewart F, Finn MB, Cairns NJ, Verghese PB, Fogelman I, West T, Braunstein J, Robinson G, Keyser J, Roh J, Knapik SS, Hu Y, Holtzman DM. Yanamandra K, et al. Sci Transl Med. 2017 Apr 19;9(386):eaal2029. doi: 10.1126/scitranslmed.aal2029. Sci Transl Med. 2017. PMID: 28424326 Free PMC article.
A blood-based diagnostic test incorporating plasma Aβ42/40 ratio, ApoE proteotype, and age accurately identifies brain amyloid status: findings from a multi cohort validity analysis.
West T, Kirmess KM, Meyer MR, Holubasch MS, Knapik SS, Hu Y, Contois JH, Jackson EN, Harpstrite SE, Bateman RJ, Holtzman DM, Verghese PB, Fogelman I, Braunstein JB, Yarasheski KE. West T, et al. Among authors: braunstein jb. Mol Neurodegener. 2021 May 1;16(1):30. doi: 10.1186/s13024-021-00451-6. Mol Neurodegener. 2021. PMID: 33933117 Free PMC article.
Assessment of a Plasma Amyloid Probability Score to Estimate Amyloid Positron Emission Tomography Findings Among Adults With Cognitive Impairment.
Hu Y, Kirmess KM, Meyer MR, Rabinovici GD, Gatsonis C, Siegel BA, Whitmer RA, Apgar C, Hanna L, Kanekiyo M, Kaplow J, Koyama A, Verbel D, Holubasch MS, Knapik SS, Connor J, Contois JH, Jackson EN, Harpstrite SE, Bateman RJ, Holtzman DM, Verghese PB, Fogelman I, Braunstein JB, Yarasheski KE, West T. Hu Y, et al. Among authors: braunstein jb. JAMA Netw Open. 2022 Apr 1;5(4):e228392. doi: 10.1001/jamanetworkopen.2022.8392. JAMA Netw Open. 2022. PMID: 35446396 Free PMC article.
Blood Biomarkers from Research Use to Clinical Practice: What Must Be Done? A Report from the EU/US CTAD Task Force.
Angioni D, Delrieu J, Hansson O, Fillit H, Aisen P, Cummings J, Sims JR, Braunstein JB, Sabbagh M, Bittner T, Pontecorvo M, Bozeat S, Dage JL, Largent E, Mattke S, Correa O, Gutierrez Robledo LM, Baldivieso V, Willis DR, Atri A, Bateman RJ, Ousset PJ, Vellas B, Weiner M. Angioni D, et al. Among authors: braunstein jb. J Prev Alzheimers Dis. 2022;9(4):569-579. doi: 10.14283/jpad.2022.85. J Prev Alzheimers Dis. 2022. PMID: 36281661 Free PMC article.
Independent study demonstrates amyloid probability score accurately indicates amyloid pathology.
Fogelman I, West T, Braunstein JB, Verghese PB, Kirmess KM, Meyer MR, Contois JH, Shobin E, Ferber KL, Gagnon J, Rubel CE, Graham D, Bateman RJ, Holtzman DM, Huang S, Yu J, Yang S, Yarasheski KE. Fogelman I, et al. Among authors: braunstein jb. Ann Clin Transl Neurol. 2023 May;10(5):765-778. doi: 10.1002/acn3.51763. Epub 2023 Mar 28. Ann Clin Transl Neurol. 2023. PMID: 36975407 Free PMC article.
Can We Use Blood Biomarkers as Entry Criteria and for Monitoring Drug Treatment Effects in Clinical Trials? A Report from the EU/US CTAD Task Force.
Angioni D, Hansson O, Bateman RJ, Rabe C, Toloue M, Braunstein JB, Agus S, Sims JR, Bittner T, Carrillo MC, Fillit H, Masters CL, Salloway S, Aisen P, Weiner M, Vellas B, Gauthier S. Angioni D, et al. Among authors: braunstein jb. J Prev Alzheimers Dis. 2023;10(3):418-425. doi: 10.14283/jpad.2023.68. J Prev Alzheimers Dis. 2023. PMID: 37357282
A blood biomarker test for brain amyloid impacts the clinical evaluation of cognitive impairment.
Monane M, Johnson KG, Snider BJ, Turner RS, Drake JD, Maraganore DM, Bicksel JL, Jacobs DH, Ortega JL, Henderson J, Jiang Y, Huang S, Coppinger J, Fogelman I, West T, Braunstein JB. Monane M, et al. Among authors: braunstein jb. Ann Clin Transl Neurol. 2023 Oct;10(10):1738-1748. doi: 10.1002/acn3.51863. Epub 2023 Aug 7. Ann Clin Transl Neurol. 2023. PMID: 37550958 Free PMC article.
62 results