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Dual glucagon-like peptide-1 and glucagon receptor agonism reduces energy intake in type 2 diabetes with obesity.
Golubic R, Kennet J, Parker V, Robertson D, Luo D, Hansen L, Jermutus L, Ambery P, Ryaboshapkina M, Surakala M, Laker RC, Venables M, Koulman A, Park A, Evans M. Golubic R, et al. Among authors: laker rc. Diabetes Obes Metab. 2024 Jul;26(7):2634-2644. doi: 10.1111/dom.15579. Epub 2024 Apr 1. Diabetes Obes Metab. 2024. PMID: 38562018 Clinical Trial.
Hepatic glucagon action: beyond glucose mobilization.
Kajani S, Laker RC, Ratkova E, Will S, Rhodes CJ. Kajani S, et al. Among authors: laker rc. Physiol Rev. 2024 Jul 1;104(3):1021-1060. doi: 10.1152/physrev.00028.2023. Epub 2024 Feb 1. Physiol Rev. 2024. PMID: 38300523 Review.
Peptide-YY3-36/glucagon-like peptide-1 combination treatment of obese diabetic mice improves insulin sensitivity associated with recovered pancreatic β-cell function and synergistic activation of discrete hypothalamic and brainstem neuronal circuitries.
Boland BB, Laker RC, O'Brien S, Sitaula S, Sermadiras I, Nielsen JC, Barkholt P, Roostalu U, Hecksher-Sørensen J, Sejthen SR, Thorbek DD, Suckow A, Burmeister N, Oldham S, Will S, Howard VG, Gill BM, Newton P, Naylor J, Hornigold DC, Austin J, Lantier L, McGuinness OP, Trevaskis JL, Grimsby JS, Rhodes CJ. Boland BB, et al. Among authors: laker rc. Mol Metab. 2022 Jan;55:101392. doi: 10.1016/j.molmet.2021.101392. Epub 2021 Nov 12. Mol Metab. 2022. PMID: 34781035 Free PMC article.
Disrupted circadian oscillations in type 2 diabetes are linked to altered rhythmic mitochondrial metabolism in skeletal muscle.
Gabriel BM, Altıntaş A, Smith JAB, Sardon-Puig L, Zhang X, Basse AL, Laker RC, Gao H, Liu Z, Dollet L, Treebak JT, Zorzano A, Huo Z, Rydén M, Lanner JT, Esser KA, Barrès R, Pillon NJ, Krook A, Zierath JR. Gabriel BM, et al. Among authors: laker rc. Sci Adv. 2021 Oct 22;7(43):eabi9654. doi: 10.1126/sciadv.abi9654. Epub 2021 Oct 20. Sci Adv. 2021. PMID: 34669477 Free PMC article.
Mitochondria-localized AMPK responds to local energetics and contributes to exercise and energetic stress-induced mitophagy.
Drake JC, Wilson RJ, Laker RC, Guan Y, Spaulding HR, Nichenko AS, Shen W, Shang H, Dorn MV, Huang K, Zhang M, Bandara AB, Brisendine MH, Kashatus JA, Sharma PR, Young A, Gautam J, Cao R, Wallrabe H, Chang PA, Wong M, Desjardins EM, Hawley SA, Christ GJ, Kashatus DF, Miller CL, Wolf MJ, Periasamy A, Steinberg GR, Hardie DG, Yan Z. Drake JC, et al. Among authors: laker rc. Proc Natl Acad Sci U S A. 2021 Sep 14;118(37):e2025932118. doi: 10.1073/pnas.2025932118. Proc Natl Acad Sci U S A. 2021. PMID: 34493662 Free PMC article.
Resolution of NASH and hepatic fibrosis by the GLP-1R/GcgR dual-agonist Cotadutide via modulating mitochondrial function and lipogenesis.
Boland ML, Laker RC, Mather K, Nawrocki A, Oldham S, Boland BB, Lewis H, Conway J, Naylor J, Guionaud S, Feigh M, Veidal SS, Lantier L, McGuinness OP, Grimsby J, Rondinone CM, Jermutus L, Larsen MR, Trevaskis JL, Rhodes CJ. Boland ML, et al. Among authors: laker rc. Nat Metab. 2020 May;2(5):413-431. doi: 10.1038/s42255-020-0209-6. Epub 2020 May 21. Nat Metab. 2020. PMID: 32478287 Free PMC article.
31 results