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Antibiotics induce sustained dysregulation of intestinal T cell immunity by perturbing macrophage homeostasis.
Scott NA, Andrusaite A, Andersen P, Lawson M, Alcon-Giner C, Leclaire C, Caim S, Le Gall G, Shaw T, Connolly JPR, Roe AJ, Wessel H, Bravo-Blas A, Thomson CA, Kästele V, Wang P, Peterson DA, Bancroft A, Li X, Grencis R, Mowat AM, Hall LJ, Travis MA, Milling SWF, Mann ER. Scott NA, et al. Among authors: mann er. Sci Transl Med. 2018 Oct 24;10(464):eaao4755. doi: 10.1126/scitranslmed.aao4755. Sci Transl Med. 2018. PMID: 30355800 Free PMC article.
Longitudinal immune profiling reveals key myeloid signatures associated with COVID-19.
Mann ER, Menon M, Knight SB, Konkel JE, Jagger C, Shaw TN, Krishnan S, Rattray M, Ustianowski A, Bakerly ND, Dark P, Lord G, Simpson A, Felton T, Ho LP; NIHR Respiratory TRC,; Feldmann M; CIRCO,; Grainger JR, Hussell T. Mann ER, et al. Sci Immunol. 2020 Sep 17;5(51):eabd6197. doi: 10.1126/sciimmunol.abd6197. Sci Immunol. 2020. PMID: 32943497 Free PMC article.
Microbiota Sensing by Mincle-Syk Axis in Dendritic Cells Regulates Interleukin-17 and -22 Production and Promotes Intestinal Barrier Integrity.
Martínez-López M, Iborra S, Conde-Garrosa R, Mastrangelo A, Danne C, Mann ER, Reid DM, Gaboriau-Routhiau V, Chaparro M, Lorenzo MP, Minnerup L, Saz-Leal P, Slack E, Kemp B, Gisbert JP, Dzionek A, Robinson MJ, Rupérez FJ, Cerf-Bensussan N, Brown GD, Bernardo D, LeibundGut-Landmann S, Sancho D. Martínez-López M, et al. Among authors: mann er. Immunity. 2019 Feb 19;50(2):446-461.e9. doi: 10.1016/j.immuni.2018.12.020. Epub 2019 Jan 29. Immunity. 2019. PMID: 30709742 Free PMC article.
Patients with gastrointestinal irritability after TGN1412-induced cytokine storm displayed selective expansion of gut-homing αβ and γδT cells.
McCarthy NE, Stagg AJ, Price CL, Mann ER, Gellatly NL, Al-Hassi HO, Knight SC, Panoskaltsis N. McCarthy NE, et al. Among authors: mann er. Cancer Immunol Immunother. 2021 Apr;70(4):1143-1153. doi: 10.1007/s00262-020-02723-4. Epub 2020 Oct 13. Cancer Immunol Immunother. 2021. PMID: 33048222 Free PMC article. Clinical Trial.
Alterations in T and B cell function persist in convalescent COVID-19 patients.
Shuwa HA, Shaw TN, Knight SB, Wemyss K, McClure FA, Pearmain L, Prise I, Jagger C, Morgan DJ, Khan S, Brand O, Mann ER, Ustianowski A, Bakerly ND, Dark P, Brightling CE, Brij S; CIRCO; Felton T, Simpson A, Grainger JR, Hussell T, Konkel JE, Menon M. Shuwa HA, et al. Among authors: mann er. Med. 2021 Jun 11;2(6):720-735.e4. doi: 10.1016/j.medj.2021.03.013. Epub 2021 Mar 31. Med. 2021. PMID: 33821250 Free PMC article.
38 results