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Receptor transfer between immune cells by autoantibody-enhanced, CD32-driven trogocytosis is hijacked by HIV-1 to infect resting CD4 T cells.
Albanese M, Chen HR, Gapp M, Muenchhoff M, Yang HH, Peterhoff D, Hoffmann K, Xiao Q, Ruhle A, Ambiel I, Schneider S, Mejías-Pérez E, Stern M, Wratil PR, Hofmann K, Amann L, Jocham L, Fuchs T, Ulivi AF, Besson-Girard S, Weidlich S, Schneider J, Spinner CD, Sutter K, Dittmer U, Humpe A, Baumeister P, Wieser A, Rothenfusser S, Bogner J, Roider J, Knolle P, Hengel H, Wagner R, Laketa V, Fackler OT, Keppler OT. Albanese M, et al. Among authors: fackler ot. Cell Rep Med. 2024 Apr 16;5(4):101483. doi: 10.1016/j.xcrm.2024.101483. Epub 2024 Apr 4. Cell Rep Med. 2024. PMID: 38579727 Free PMC article.
The Nef protein of human immunodeficiency virus is a broad-spectrum modulator of chemokine receptor cell surface levels that acts independently of classical motifs for receptor endocytosis and Galphai signaling.
Michel N, Ganter K, Venzke S, Bitzegeio J, Fackler OT, Keppler OT. Michel N, et al. Among authors: fackler ot. Mol Biol Cell. 2006 Aug;17(8):3578-90. doi: 10.1091/mbc.e06-02-0117. Epub 2006 Jun 14. Mol Biol Cell. 2006. PMID: 16775006 Free PMC article.
HIV-1 antagonism of CD317 is species specific and involves Vpu-mediated proteasomal degradation of the restriction factor.
Goffinet C, Allespach I, Homann S, Tervo HM, Habermann A, Rupp D, Oberbremer L, Kern C, Tibroni N, Welsch S, Krijnse-Locker J, Banting G, Kräusslich HG, Fackler OT, Keppler OT. Goffinet C, et al. Among authors: fackler ot. Cell Host Microbe. 2009 Mar 19;5(3):285-97. doi: 10.1016/j.chom.2009.01.009. Cell Host Microbe. 2009. PMID: 19286137 Free article.
155 results