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Receptor transfer between immune cells by autoantibody-enhanced, CD32-driven trogocytosis is hijacked by HIV-1 to infect resting CD4 T cells.
Albanese M, Chen HR, Gapp M, Muenchhoff M, Yang HH, Peterhoff D, Hoffmann K, Xiao Q, Ruhle A, Ambiel I, Schneider S, Mejías-Pérez E, Stern M, Wratil PR, Hofmann K, Amann L, Jocham L, Fuchs T, Ulivi AF, Besson-Girard S, Weidlich S, Schneider J, Spinner CD, Sutter K, Dittmer U, Humpe A, Baumeister P, Wieser A, Rothenfusser S, Bogner J, Roider J, Knolle P, Hengel H, Wagner R, Laketa V, Fackler OT, Keppler OT. Albanese M, et al. Among authors: keppler ot. Cell Rep Med. 2024 Apr 16;5(4):101483. doi: 10.1016/j.xcrm.2024.101483. Epub 2024 Apr 4. Cell Rep Med. 2024. PMID: 38579727 Free PMC article.
Spatial resolution of HIV-1 post-entry steps in resting CD4 T cells.
Ananth S, Ambiel I, Schifferdecker S, Müller TG, Wratil PR, Mejias-Perez E, Kräusslich HG, Müller B, Keppler OT, Fackler OT. Ananth S, et al. Among authors: keppler ot. Cell Rep. 2024 Mar 26;43(3):113941. doi: 10.1016/j.celrep.2024.113941. Epub 2024 Mar 12. Cell Rep. 2024. PMID: 38478523 Free article.
MxB/Mx2: the latest piece in HIV's interferon puzzle.
Fackler OT, Keppler OT. Fackler OT, et al. Among authors: keppler ot. EMBO Rep. 2013 Dec;14(12):1028-9. doi: 10.1038/embor.2013.172. Epub 2013 Nov 1. EMBO Rep. 2013. PMID: 24176933 Free PMC article. No abstract available.
Evidence for increased SARS-CoV-2 susceptibility and COVID-19 severity related to pre-existing immunity to seasonal coronaviruses.
Wratil PR, Schmacke NA, Karakoc B, Dulovic A, Junker D, Becker M, Rothbauer U, Osterman A, Spaeth PM, Ruhle A, Gapp M, Schneider S, Muenchhoff M, Hellmuth JC, Scherer C, Mayerle J, Reincke M, Behr J, Kääb S, Zwissler B, von Bergwelt-Baildon M, Eberle J, Kaderali L, Schneiderhan-Marra N, Hornung V, Keppler OT. Wratil PR, et al. Among authors: keppler ot. Cell Rep. 2021 Dec 28;37(13):110169. doi: 10.1016/j.celrep.2021.110169. Epub 2021 Dec 7. Cell Rep. 2021. PMID: 34932974 Free PMC article.
Rapid, efficient and activation-neutral gene editing of polyclonal primary human resting CD4+ T cells allows complex functional analyses.
Albanese M, Ruhle A, Mittermaier J, Mejías-Pérez E, Gapp M, Linder A, Schmacke NA, Hofmann K, Hennrich AA, Levy DN, Humpe A, Conzelmann KK, Hornung V, Fackler OT, Keppler OT. Albanese M, et al. Among authors: keppler ot. Nat Methods. 2022 Jan;19(1):81-89. doi: 10.1038/s41592-021-01328-8. Epub 2021 Dec 23. Nat Methods. 2022. PMID: 34949807 Free PMC article.
SAMHD1 restricts HIV-1 infection in resting CD4(+) T cells.
Baldauf HM, Pan X, Erikson E, Schmidt S, Daddacha W, Burggraf M, Schenkova K, Ambiel I, Wabnitz G, Gramberg T, Panitz S, Flory E, Landau NR, Sertel S, Rutsch F, Lasitschka F, Kim B, König R, Fackler OT, Keppler OT. Baldauf HM, et al. Among authors: keppler ot. Nat Med. 2012 Nov;18(11):1682-7. doi: 10.1038/nm.2964. Nat Med. 2012. PMID: 22972397 Free PMC article.
171 results