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Large-scale RNA-seq mining reveals ciclopirox triggers TDP-43 cryptic exons.
Sinha IR, Sandal PS, Burns GD, Mallika AP, Irwin KE, Cruz ALF, Wang V, Rodríguez JL, Wong PC, Ling JP. Sinha IR, et al. Among authors: ling jp. bioRxiv [Preprint]. 2024 Mar 30:2024.03.27.587011. doi: 10.1101/2024.03.27.587011. bioRxiv. 2024. PMID: 38585725 Free PMC article. Preprint.
A fluid biomarker reveals loss of TDP-43 splicing repression in pre-symptomatic ALS.
Irwin KE, Jasin P, Braunstein KE, Sinha I, Bowden KD, Moghekar A, Oh ES, Raitcheva D, Bartlett D, Berry JD, Traynor B, Ling JP, Wong PC. Irwin KE, et al. Among authors: ling jp. bioRxiv [Preprint]. 2023 Jan 24:2023.01.23.525202. doi: 10.1101/2023.01.23.525202. bioRxiv. 2023. PMID: 36789434 Free PMC article. Updated. Preprint.
Elevated nuclear TDP-43 induces constitutive exon skipping.
Carmen-Orozco RP, Tsao W, Ye Y, Sinha IR, Chang K, Trinh V, Chung W, Bowden K, Troncoso JC, Blackshaw S, Hayes LR, Sun S, Wong PC, Ling JP. Carmen-Orozco RP, et al. Among authors: ling jp. bioRxiv [Preprint]. 2023 May 12:2023.05.11.540291. doi: 10.1101/2023.05.11.540291. bioRxiv. 2023. PMID: 37215013 Free PMC article. Preprint.
A fluid biomarker reveals loss of TDP-43 splicing repression in presymptomatic ALS-FTD.
Irwin KE, Jasin P, Braunstein KE, Sinha IR, Garret MA, Bowden KD, Chang K, Troncoso JC, Moghekar A, Oh ES, Raitcheva D, Bartlett D, Miller T, Berry JD, Traynor BJ, Ling JP, Wong PC. Irwin KE, et al. Among authors: ling jp. Nat Med. 2024 Feb;30(2):382-393. doi: 10.1038/s41591-023-02788-5. Epub 2024 Jan 26. Nat Med. 2024. PMID: 38278991 Free PMC article.
Tdp-43 cryptic exons are highly variable between cell types.
Jeong YH, Ling JP, Lin SZ, Donde AN, Braunstein KE, Majounie E, Traynor BJ, LaClair KD, Lloyd TE, Wong PC. Jeong YH, et al. Among authors: ling jp. Mol Neurodegener. 2017 Feb 2;12(1):13. doi: 10.1186/s13024-016-0144-x. Mol Neurodegener. 2017. PMID: 28153034 Free PMC article.
Author Correction: A fluid biomarker reveals loss of TDP-43 splicing repression in presymptomatic ALS-FTD.
Irwin KE, Jasin P, Braunstein KE, Sinha IR, Garret MA, Bowden KD, Chang K, Troncoso JC, Moghekar A, Oh ES, Raitcheva D, Bartlett D, Miller T, Berry JD, Traynor BJ, Ling JP, Wong PC. Irwin KE, et al. Among authors: ling jp. Nat Med. 2024 May;30(5):1504. doi: 10.1038/s41591-024-02966-z. Nat Med. 2024. PMID: 38580817 Free PMC article. No abstract available.
Loss of TDP-43 splicing repression occurs early in the aging population and is associated with Alzheimer's disease neuropathologic changes and cognitive decline.
Chang K, Ling JP, Redding-Ochoa J, An Y, Li L, Dean SA, Blanchard TG, Pylyukh T, Barrett A, Irwin KE, Moghekar A, Resnick SM, Wong PC, Troncoso JC. Chang K, et al. Among authors: ling jp. Acta Neuropathol. 2023 Dec 22;147(1):4. doi: 10.1007/s00401-023-02653-2. Acta Neuropathol. 2023. PMID: 38133681
PTBP1 and PTBP2 Repress Nonconserved Cryptic Exons.
Ling JP, Chhabra R, Merran JD, Schaughency PM, Wheelan SJ, Corden JL, Wong PC. Ling JP, et al. Cell Rep. 2016 Sep 27;17(1):104-113. doi: 10.1016/j.celrep.2016.08.071. Cell Rep. 2016. PMID: 27681424 Free PMC article.
Rodent models of TDP-43: recent advances.
Tsao W, Jeong YH, Lin S, Ling J, Price DL, Chiang PM, Wong PC. Tsao W, et al. Brain Res. 2012 Jun 26;1462:26-39. doi: 10.1016/j.brainres.2012.04.031. Epub 2012 May 1. Brain Res. 2012. PMID: 22608070 Free PMC article. Review.
29 results