Tesmer JJG - Search Results

1

Structure of adenylyl cyclase 5 in complex with Gβγ offers insights into ADCY5-related dyskinesia.

Yen YC, Li Y, Chen CL, Klose T, Watts VJ, Dessauer CW, Tesmer JJG. Yen YC, et al. Among authors: tesmer jjg. Nat Struct Mol Biol. 2024 Apr 8. doi: 10.1038/s41594-024-01263-0. Online ahead of print. Nat Struct Mol Biol. 2024. PMID: 38589608

2

Molecular basis for Gβγ-mediated activation of phosphoinositide 3-kinase γ.

Chen CL, Syahirah R, Ravala SK, Yen YC, Klose T, Deng Q, Tesmer JJG. Chen CL, et al. Among authors: tesmer jjg. Nat Struct Mol Biol. 2024 Apr 2. doi: 10.1038/s41594-024-01265-y. Online ahead of print. Nat Struct Mol Biol. 2024. PMID: 38565696

3

Identification of a Gialpha binding site on type V adenylyl cyclase.

Dessauer CW, Tesmer JJ, Sprang SR, Gilman AG. Dessauer CW, et al. J Biol Chem. 1998 Oct 2;273(40):25831-9. doi: 10.1074/jbc.273.40.25831. J Biol Chem. 1998. PMID: 9748257 Free article.

4

Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1.

Chen Q, Plasencia M, Li Z, Mukherjee S, Patra D, Chen CL, Klose T, Yao XQ, Kossiakoff AA, Chang L, Andrews PC, Tesmer JJG. Chen Q, et al. Among authors: tesmer jjg. Nature. 2021 Jul;595(7868):600-605. doi: 10.1038/s41586-021-03721-x. Epub 2021 Jul 14. Nature. 2021. PMID: 34262173 Free PMC article.

5

The interactions of adenylate cyclases with P-site inhibitors.

Dessauer CW, Tesmer JJ, Sprang SR, Gilman AG. Dessauer CW, et al. Trends Pharmacol Sci. 1999 May;20(5):205-10. doi: 10.1016/s0165-6147(99)01310-3. Trends Pharmacol Sci. 1999. PMID: 10354616 Review.

6

Molecular basis for P-site inhibition of adenylyl cyclase.

Tesmer JJ, Dessauer CW, Sunahara RK, Murray LD, Johnson RA, Gilman AG, Sprang SR. Tesmer JJ, et al. Biochemistry. 2000 Nov 28;39(47):14464-71. doi: 10.1021/bi0015562. Biochemistry. 2000. PMID: 11087399

7

A New Paroxetine-Based GRK2 Inhibitor Reduces Internalization of the μ-Opioid Receptor.

Bouley RA, Weinberg ZY, Waldschmidt HV, Yen YC, Larsen SD, Puthenveedu MA, Tesmer JJG. Bouley RA, et al. Among authors: tesmer jjg. Mol Pharmacol. 2020 Jun;97(6):392-401. doi: 10.1124/mol.119.118661. Epub 2020 Mar 31. Mol Pharmacol. 2020. PMID: 32234810 Free PMC article.

8

The Open Question of How GPCRs Interact with GPCR Kinases (GRKs).

Cato MC, Yen YC, Francis CJ, Elkins KE, Shareef A, Sterne-Marr R, Tesmer JJG. Cato MC, et al. Among authors: tesmer jjg. Biomolecules. 2021 Mar 17;11(3):447. doi: 10.3390/biom11030447. Biomolecules. 2021. PMID: 33802765 Free PMC article.

9

Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias.

Yen YC, Schafer CT, Gustavsson M, Eberle SA, Dominik PK, Deneka D, Zhang P, Schall TJ, Kossiakoff AA, Tesmer JJG, Handel TM. Yen YC, et al. Among authors: tesmer jjg. Sci Adv. 2022 Jul 15;8(28):eabn8063. doi: 10.1126/sciadv.abn8063. Epub 2022 Jul 13. Sci Adv. 2022. PMID: 35857509 Free PMC article.

10

Structural/functional studies of Trio provide insights into its configuration and show that conserved linker elements enhance its activity for Rac1.

Bandekar SJ, Chen CL, Ravala SK, Cash JN, Avramova LV, Zhalnina MV, Gutkind JS, Li S, Tesmer JJG. Bandekar SJ, et al. Among authors: tesmer jjg. J Biol Chem. 2022 Aug;298(8):102209. doi: 10.1016/j.jbc.2022.102209. Epub 2022 Jun 30. J Biol Chem. 2022. PMID: 35779635 Free PMC article.

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