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Early antiretroviral therapy in SIV-infected rhesus macaques reveals a multiphasic, saturable dynamic accumulation of the rebound competent viral reservoir.
Keele BF, Okoye AA, Fennessey CM, Varco-Merth B, Immonen TT, Kose E, Conchas A, Pinkevych M, Lipkey L, Newman L, Macairan A, Bosche M, Bosche WJ, Berkemeier B, Fast R, Hull M, Oswald K, Shoemaker R, Silipino L, Gorelick RJ, Duell D, Marenco A, Brantley W, Smedley J, Axthelm M, Davenport MP, Lifson JD, Picker LJ. Keele BF, et al. Among authors: gorelick rj. PLoS Pathog. 2024 Apr 9;20(4):e1012135. doi: 10.1371/journal.ppat.1012135. eCollection 2024 Apr. PLoS Pathog. 2024. PMID: 38593120 Free PMC article.
Immune reconstitution inflammatory syndrome drives emergence of HIV drug resistance from multiple anatomic compartments in a person living with HIV.
Lisco A, Lange C, Manion M, Kuriakose S, Dewar R, Gorelick RJ, Huik K, Yu Q, Hammoud DA, Smith BR, Muranski P, Rehm C, Sherman BT, Sykes C, Lindo N, Ye P, Bricker KM, Keele BF, Fennessey CM, Maldarelli F, Sereti I. Lisco A, et al. Among authors: gorelick rj. Nat Med. 2023 Jun;29(6):1364-1369. doi: 10.1038/s41591-023-02387-4. Epub 2023 Jun 15. Nat Med. 2023. PMID: 37322122 Free PMC article.
Long-acting lenacapavir protects macaques against intravenous challenge with simian-tropic HIV.
Swanstrom AE, Gorelick RJ, Welker JL, Schmidt F, Lu B, Wang K, Rowe W, Breed MW, Killoran KE, Kramer JA, Donohue D, Roser JD, Bieniasz PD, Hatziioannou T, Pyle C, Thomas JA, Trubey CM, Zheng J, Blair W, Yant SR, Lifson JD, Del Prete GQ. Swanstrom AE, et al. Among authors: gorelick rj. EBioMedicine. 2023 Sep;95:104764. doi: 10.1016/j.ebiom.2023.104764. Epub 2023 Aug 23. EBioMedicine. 2023. PMID: 37625266 Free PMC article.
An open label randomized controlled trial of atorvastatin versus aspirin in elite controllers and antiretroviral-treated people with HIV.
Mystakelis HA, Wilson E, Laidlaw E, Poole A, Krishnan S, Rupert A, Welker JL, Gorelick RJ, Lisco A, Manion M, Baker JV, Migueles SA, Sereti I. Mystakelis HA, et al. Among authors: gorelick rj. AIDS. 2023 Oct 1;37(12):1827-1835. doi: 10.1097/QAD.0000000000003656. Epub 2023 Jul 24. AIDS. 2023. PMID: 37450602 Free PMC article. Clinical Trial.
Pembrolizumab induces HIV latency reversal in people living with HIV and cancer on antiretroviral therapy.
Uldrick TS, Adams SV, Fromentin R, Roche M, Fling SP, Gonçalves PH, Lurain K, Ramaswami R, Wang CJ, Gorelick RJ, Welker JL, O'Donoghue L, Choudhary H, Lifson JD, Rasmussen TA, Rhodes A, Tumpach C, Yarchoan R, Maldarelli F, Cheever MA, Sékaly R, Chomont N, Deeks SG, Lewin SR. Uldrick TS, et al. Among authors: gorelick rj. Sci Transl Med. 2022 Jan 26;14(629):eabl3836. doi: 10.1126/scitranslmed.abl3836. Epub 2022 Jan 26. Sci Transl Med. 2022. PMID: 35080914 Free PMC article.
The HIV-1 Nucleocapsid Regulates Its Own Condensation by Phase-Separated Activity-Enhancing Sequestration of the Viral Protease during Maturation.
Lyonnais S, Sadiq SK, Lorca-Oró C, Dufau L, Nieto-Marquez S, Escribà T, Gabrielli N, Tan X, Ouizougun-Oubari M, Okoronkwo J, Reboud-Ravaux M, Gatell JM, Marquet R, Paillart JC, Meyerhans A, Tisné C, Gorelick RJ, Mirambeau G. Lyonnais S, et al. Among authors: gorelick rj. Viruses. 2021 Nov 19;13(11):2312. doi: 10.3390/v13112312. Viruses. 2021. PMID: 34835118 Free PMC article.
Stable Latent HIV Infection and Low-level Viremia Despite Treatment With the Broadly Neutralizing Antibody VRC07-523LS and the Latency Reversal Agent Vorinostat.
Gay CL, James KS, Tuyishime M, Falcinelli SD, Joseph SB, Moeser MJ, Allard B, Kirchherr JL, Clohosey M, Raines SLM, Montefiori DC, Shen X, Gorelick RJ, Gama L, McDermott AB, Koup RA, Mascola JR, Floris-Moore M, Kuruc JD, Ferrari G, Eron JJ, Archin NM, Margolis DM. Gay CL, et al. Among authors: gorelick rj. J Infect Dis. 2022 Mar 2;225(5):856-861. doi: 10.1093/infdis/jiab487. J Infect Dis. 2022. PMID: 34562096 Free PMC article.
Prevalence and risk of residual viremia after ART in low- and middle-income countries: A cross-sectional study.
Gatechompol S, Zheng L, Bao Y, Avihingsanon A, Kerr SJ, Kumarasamy N, Hakim JG, Maldarelli F, Gorelick RJ, Welker JL, Lifson JD, Hosseinipour MC, Eron JJ, Ruxrungtham K. Gatechompol S, et al. Among authors: gorelick rj. Medicine (Baltimore). 2021 Sep 3;100(35):e26817. doi: 10.1097/MD.0000000000026817. Medicine (Baltimore). 2021. PMID: 34477118 Free PMC article.
138 results