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Early antiretroviral therapy in SIV-infected rhesus macaques reveals a multiphasic, saturable dynamic accumulation of the rebound competent viral reservoir.
Keele BF, Okoye AA, Fennessey CM, Varco-Merth B, Immonen TT, Kose E, Conchas A, Pinkevych M, Lipkey L, Newman L, Macairan A, Bosche M, Bosche WJ, Berkemeier B, Fast R, Hull M, Oswald K, Shoemaker R, Silipino L, Gorelick RJ, Duell D, Marenco A, Brantley W, Smedley J, Axthelm M, Davenport MP, Lifson JD, Picker LJ. Keele BF, et al. Among authors: newman l. PLoS Pathog. 2024 Apr 9;20(4):e1012135. doi: 10.1371/journal.ppat.1012135. eCollection 2024 Apr. PLoS Pathog. 2024. PMID: 38593120 Free PMC article.
Genetically-barcoded SIV facilitates enumeration of rebound variants and estimation of reactivation rates in nonhuman primates following interruption of suppressive antiretroviral therapy.
Fennessey CM, Pinkevych M, Immonen TT, Reynaldi A, Venturi V, Nadella P, Reid C, Newman L, Lipkey L, Oswald K, Bosche WJ, Trivett MT, Ohlen C, Ott DE, Estes JD, Del Prete GQ, Lifson JD, Davenport MP, Keele BF. Fennessey CM, et al. Among authors: newman l. PLoS Pathog. 2017 May 4;13(5):e1006359. doi: 10.1371/journal.ppat.1006359. eCollection 2017 May. PLoS Pathog. 2017. PMID: 28472156 Free PMC article.
Defining early SIV replication and dissemination dynamics following vaginal transmission.
Deleage C, Immonen TT, Fennessey CM, Reynaldi A, Reid C, Newman L, Lipkey L, Schlub TE, Camus C, O'Brien S, Smedley J, Conway JM, Del Prete GQ, Davenport MP, Lifson JD, Estes JD, Keele BF. Deleage C, et al. Among authors: newman l. Sci Adv. 2019 May 29;5(5):eaav7116. doi: 10.1126/sciadv.aav7116. eCollection 2019 May. Sci Adv. 2019. PMID: 31149634 Free PMC article.
Evaluating the Intactness of Persistent Viral Genomes in Simian Immunodeficiency Virus-Infected Rhesus Macaques after Initiating Antiretroviral Therapy within One Year of Infection.
Long S, Fennessey CM, Newman L, Reid C, O'Brien SP, Li Y, Del Prete GQ, Lifson JD, Gorelick RJ, Keele BF. Long S, et al. Among authors: newman l. J Virol. 2019 Dec 12;94(1):e01308-19. doi: 10.1128/JVI.01308-19. Print 2019 Dec 12. J Virol. 2019. PMID: 31597776 Free PMC article.
Antibody-mediated depletion of viral reservoirs is limited in SIV-infected macaques treated early with antiretroviral therapy.
Swanstrom AE, Immonen TT, Oswald K, Pyle C, Thomas JA, Bosche WJ, Silipino L, Hull M, Newman L, Coalter V, Wiles A, Wiles R, Kiser J, Morcock DR, Shoemaker R, Fast R, Breed MW, Kramer J, Donohue D, Malys T, Fennessey CM, Trubey CM, Deleage C, Estes JD, Lifson JD, Keele BF, Del Prete GQ. Swanstrom AE, et al. Among authors: newman l. J Clin Invest. 2021 Mar 15;131(6):e142421. doi: 10.1172/JCI142421. J Clin Invest. 2021. PMID: 33465055 Free PMC article.
Comparative characterization of transfection- and infection-derived simian immunodeficiency virus challenge stocks for in vivo nonhuman primate studies.
Del Prete GQ, Scarlotta M, Newman L, Reid C, Parodi LM, Roser JD, Oswald K, Marx PA, Miller CJ, Desrosiers RC, Barouch DH, Pal R, Piatak M Jr, Chertova E, Giavedoni LD, O'Connor DH, Lifson JD, Keele BF. Del Prete GQ, et al. Among authors: newman l. J Virol. 2013 Apr;87(8):4584-95. doi: 10.1128/JVI.03507-12. Epub 2013 Feb 13. J Virol. 2013. PMID: 23408608 Free PMC article.
Molecularly tagged simian immunodeficiency virus SIVmac239 synthetic swarm for tracking independent infection events.
Del Prete GQ, Park H, Fennessey CM, Reid C, Lipkey L, Newman L, Oswald K, Kahl C, Piatak M Jr, Quiñones OA, Alvord WG, Smedley J, Estes JD, Lifson JD, Picker LJ, Keele BF. Del Prete GQ, et al. Among authors: newman l. J Virol. 2014 Jul;88(14):8077-90. doi: 10.1128/JVI.01026-14. Epub 2014 May 7. J Virol. 2014. PMID: 24807714 Free PMC article.
Derivation and Characterization of Pathogenic Transmitted/Founder Molecular Clones from Simian Immunodeficiency Virus SIVsmE660 and SIVmac251 following Mucosal Infection.
Lopker MJ, Del Prete GQ, Estes JD, Li H, Reid C, Newman L, Lipkey L, Camus C, Easlick JL, Wang S, Decker JM, Bar KJ, Learn G, Pal R, Weiss DE, Hahn BH, Lifson JD, Shaw GM, Keele BF. Lopker MJ, et al. Among authors: newman l. J Virol. 2016 Sep 12;90(19):8435-53. doi: 10.1128/JVI.00718-16. Print 2016 Oct 1. J Virol. 2016. PMID: 27412591 Free PMC article.
Vaccination against endogenous retrotransposable element consensus sequences does not protect rhesus macaques from SIVsmE660 infection and replication.
Sheppard NC, Jones RB, Burwitz BJ, Nimityongskul FA, Newman LP, Buechler MB, Reed JS, Piaskowski SM, Weisgrau KL, Castrovinci PA, Wilson NA, Ostrowski MA, Park B, Nixon DF, Rakasz EG, Sacha JB. Sheppard NC, et al. Among authors: newman lp. PLoS One. 2014 Mar 20;9(3):e92012. doi: 10.1371/journal.pone.0092012. eCollection 2014. PLoS One. 2014. PMID: 24651676 Free PMC article.
1,601 results