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Early antiretroviral therapy in SIV-infected rhesus macaques reveals a multiphasic, saturable dynamic accumulation of the rebound competent viral reservoir.
Keele BF, Okoye AA, Fennessey CM, Varco-Merth B, Immonen TT, Kose E, Conchas A, Pinkevych M, Lipkey L, Newman L, Macairan A, Bosche M, Bosche WJ, Berkemeier B, Fast R, Hull M, Oswald K, Shoemaker R, Silipino L, Gorelick RJ, Duell D, Marenco A, Brantley W, Smedley J, Axthelm M, Davenport MP, Lifson JD, Picker LJ. Keele BF, et al. Among authors: oswald k. PLoS Pathog. 2024 Apr 9;20(4):e1012135. doi: 10.1371/journal.ppat.1012135. eCollection 2024 Apr. PLoS Pathog. 2024. PMID: 38593120 Free PMC article.
Elevated Plasma Viral Loads in Romidepsin-Treated Simian Immunodeficiency Virus-Infected Rhesus Macaques on Suppressive Combination Antiretroviral Therapy.
Del Prete GQ, Oswald K, Lara A, Shoemaker R, Smedley J, Macallister R, Coalter V, Wiles A, Wiles R, Li Y, Fast R, Kiser R, Lu B, Zheng J, Alvord WG, Trubey CM, Piatak M Jr, Deleage C, Keele BF, Estes JD, Hesselgesser J, Geleziunas R, Lifson JD. Del Prete GQ, et al. Among authors: oswald k. Antimicrob Agents Chemother. 2015 Dec 28;60(3):1560-72. doi: 10.1128/AAC.02625-15. Antimicrob Agents Chemother. 2015. PMID: 26711758 Free PMC article.
Genetically-barcoded SIV facilitates enumeration of rebound variants and estimation of reactivation rates in nonhuman primates following interruption of suppressive antiretroviral therapy.
Fennessey CM, Pinkevych M, Immonen TT, Reynaldi A, Venturi V, Nadella P, Reid C, Newman L, Lipkey L, Oswald K, Bosche WJ, Trivett MT, Ohlen C, Ott DE, Estes JD, Del Prete GQ, Lifson JD, Davenport MP, Keele BF. Fennessey CM, et al. Among authors: oswald k. PLoS Pathog. 2017 May 4;13(5):e1006359. doi: 10.1371/journal.ppat.1006359. eCollection 2017 May. PLoS Pathog. 2017. PMID: 28472156 Free PMC article.
Early antiretroviral therapy limits SIV reservoir establishment to delay or prevent post-treatment viral rebound.
Okoye AA, Hansen SG, Vaidya M, Fukazawa Y, Park H, Duell DM, Lum R, Hughes CM, Ventura AB, Ainslie E, Ford JC, Morrow D, Gilbride RM, Legasse AW, Hesselgesser J, Geleziunas R, Li Y, Oswald K, Shoemaker R, Fast R, Bosche WJ, Borate BR, Edlefsen PT, Axthelm MK, Picker LJ, Lifson JD. Okoye AA, et al. Among authors: oswald k. Nat Med. 2018 Sep;24(9):1430-1440. doi: 10.1038/s41591-018-0130-7. Epub 2018 Aug 6. Nat Med. 2018. PMID: 30082858 Free PMC article.
TLR7 agonist administration to SIV-infected macaques receiving early initiated cART does not induce plasma viremia.
Del Prete GQ, Alvord WG, Li Y, Deleage C, Nag M, Oswald K, Thomas JA, Pyle C, Bosche WJ, Coalter V, Wiles A, Wiles R, Berkemeier B, Hull M, Chipriano E, Silipino L, Fast R, Kiser J, Kiser R, Malys T, Kramer J, Breed MW, Trubey CM, Estes JD, Barnes TL, Hesselgesser J, Geleziunas R, Lifson JD. Del Prete GQ, et al. Among authors: oswald k. JCI Insight. 2019 Jun 6;4(11):e127717. doi: 10.1172/jci.insight.127717. eCollection 2019 Jun 6. JCI Insight. 2019. PMID: 31167974 Free PMC article.
Antibody-mediated depletion of viral reservoirs is limited in SIV-infected macaques treated early with antiretroviral therapy.
Swanstrom AE, Immonen TT, Oswald K, Pyle C, Thomas JA, Bosche WJ, Silipino L, Hull M, Newman L, Coalter V, Wiles A, Wiles R, Kiser J, Morcock DR, Shoemaker R, Fast R, Breed MW, Kramer J, Donohue D, Malys T, Fennessey CM, Trubey CM, Deleage C, Estes JD, Lifson JD, Keele BF, Del Prete GQ. Swanstrom AE, et al. Among authors: oswald k. J Clin Invest. 2021 Mar 15;131(6):e142421. doi: 10.1172/JCI142421. J Clin Invest. 2021. PMID: 33465055 Free PMC article.
Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge.
Hansen SG, Vieville C, Whizin N, Coyne-Johnson L, Siess DC, Drummond DD, Legasse AW, Axthelm MK, Oswald K, Trubey CM, Piatak M Jr, Lifson JD, Nelson JA, Jarvis MA, Picker LJ. Hansen SG, et al. Among authors: oswald k. Nat Med. 2009 Mar;15(3):293-9. doi: 10.1038/nm.1935. Epub 2009 Feb 15. Nat Med. 2009. PMID: 19219024 Free PMC article.
Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine.
Hansen SG, Ford JC, Lewis MS, Ventura AB, Hughes CM, Coyne-Johnson L, Whizin N, Oswald K, Shoemaker R, Swanson T, Legasse AW, Chiuchiolo MJ, Parks CL, Axthelm MK, Nelson JA, Jarvis MA, Piatak M Jr, Lifson JD, Picker LJ. Hansen SG, et al. Among authors: oswald k. Nature. 2011 May 26;473(7348):523-7. doi: 10.1038/nature10003. Epub 2011 May 11. Nature. 2011. PMID: 21562493 Free PMC article.
Lymph node T cell responses predict the efficacy of live attenuated SIV vaccines.
Fukazawa Y, Park H, Cameron MJ, Lefebvre F, Lum R, Coombes N, Mahyari E, Hagen SI, Bae JY, Reyes MD 3rd, Swanson T, Legasse AW, Sylwester A, Hansen SG, Smith AT, Stafova P, Shoemaker R, Li Y, Oswald K, Axthelm MK, McDermott A, Ferrari G, Montefiori DC, Edlefsen PT, Piatak M Jr, Lifson JD, Sékaly RP, Picker LJ. Fukazawa Y, et al. Among authors: oswald k. Nat Med. 2012 Nov;18(11):1673-81. doi: 10.1038/nm.2934. Epub 2012 Sep 9. Nat Med. 2012. PMID: 22961108 Free PMC article.
Comparative characterization of transfection- and infection-derived simian immunodeficiency virus challenge stocks for in vivo nonhuman primate studies.
Del Prete GQ, Scarlotta M, Newman L, Reid C, Parodi LM, Roser JD, Oswald K, Marx PA, Miller CJ, Desrosiers RC, Barouch DH, Pal R, Piatak M Jr, Chertova E, Giavedoni LD, O'Connor DH, Lifson JD, Keele BF. Del Prete GQ, et al. Among authors: oswald k. J Virol. 2013 Apr;87(8):4584-95. doi: 10.1128/JVI.03507-12. Epub 2013 Feb 13. J Virol. 2013. PMID: 23408608 Free PMC article.
103 results