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DNAJC9 prevents CENP-A mislocalization and chromosomal instability by maintaining the fidelity of histone supply chains.
Balachandra V, Shrestha RL, Hammond CM, Lin S, Hendriks IA, Sethi SC, Chen L, Sevilla S, Caplen NJ, Chari R, Karpova TS, McKinnon K, Todd MA, Koparde V, Cheng KC, Nielsen ML, Groth A, Basrai MA. Balachandra V, et al. Among authors: chari r. EMBO J. 2024 Apr 10. doi: 10.1038/s44318-024-00093-6. Online ahead of print. EMBO J. 2024. PMID: 38600242 Free article.
A structure-based designed small molecule depletes hRpn13Pru and a select group of KEN box proteins.
Lu X, Chandravanshi M, Sabbasani VR, Gaikwad S, Hughitt VK, Gyabaah-Kessie N, Scroggins BT, Das S, Myint W, Clapp ME, Schwieters CD, Dyba MA, Bolhuis DL, Koscielniak JW, Andresson T, Emanuele MJ, Brown NG, Matsuo H, Chari R, Citrin DE, Mock BA, Swenson RE, Walters KJ. Lu X, et al. Among authors: chari r. Nat Commun. 2024 Mar 20;15(1):2485. doi: 10.1038/s41467-024-46644-7. Nat Commun. 2024. PMID: 38509117 Free PMC article.
CPAP insufficiency leads to incomplete centrioles that duplicate but fragment.
Vásquez-Limeta A, Lukasik K, Kong D, Sullenberger C, Luvsanjav D, Sahabandu N, Chari R, Loncarek J. Vásquez-Limeta A, et al. Among authors: chari r. J Cell Biol. 2022 May 2;221(5):e202108018. doi: 10.1083/jcb.202108018. Epub 2022 Apr 9. J Cell Biol. 2022. PMID: 35404385 Free PMC article.
A small protein encoded by a putative lncRNA regulates apoptosis and tumorigenicity in human colorectal cancer cells.
Li XL, Pongor L, Tang W, Das S, Muys BR, Jones MF, Lazar SB, Dangelmaier EA, Hartford CC, Grammatikakis I, Hao Q, Sun Q, Schetter A, Martindale JL, Tang B, Jenkins LM, Robles AI, Walker RL, Ambs S, Chari R, Shabalina SA, Gorospe M, Hussain SP, Harris CC, Meltzer PS, Prasanth KV, Aladjem MI, Andresson T, Lal A. Li XL, et al. Among authors: chari r. Elife. 2020 Oct 28;9:e53734. doi: 10.7554/eLife.53734. Elife. 2020. PMID: 33112233 Free PMC article.
KDM3B inhibitors disrupt the oncogenic activity of PAX3-FOXO1 in fusion-positive rhabdomyosarcoma.
Kim YY, Gryder BE, Sinniah R, Peach ML, Shern JF, Abdelmaksoud A, Pomella S, Woldemichael GM, Stanton BZ, Milewski D, Barchi JJ Jr, Schneekloth JS Jr, Chari R, Kowalczyk JT, Shenoy SR, Evans JR, Song YK, Wang C, Wen X, Chou HC, Gangalapudi V, Esposito D, Jones J, Procter L, O'Neill M, Jenkins LM, Tarasova NI, Wei JS, McMahon JB, O'Keefe BR, Hawley RG, Khan J. Kim YY, et al. Among authors: chari r. Nat Commun. 2024 Feb 24;15(1):1703. doi: 10.1038/s41467-024-45902-y. Nat Commun. 2024. PMID: 38402212 Free PMC article.
358 results