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Design and characterization of protective pan-ebolavirus and pan-filovirus bispecific antibodies.
Wirchnianski AS, Nyakatura EK, Herbert AS, Kuehne AI, Abbasi SA, Florez C, Storm N, McKay LGA, Dailey L, Kuang E, Abelson DM, Wec AZ, Chakraborti S, Holtsberg FW, Shulenin S, Bornholdt ZA, Aman MJ, Honko AN, Griffiths A, Dye JM, Chandran K, Lai JR. Wirchnianski AS, et al. Among authors: chandran k. PLoS Pathog. 2024 Apr 11;20(4):e1012134. doi: 10.1371/journal.ppat.1012134. eCollection 2024 Apr. PLoS Pathog. 2024. PMID: 38603762 Free PMC article.
Niemann-pick C1 is essential for ebolavirus replication and pathogenesis in vivo.
Herbert AS, Davidson C, Kuehne AI, Bakken R, Braigen SZ, Gunn KE, Whelan SP, Brummelkamp TR, Twenhafel NA, Chandran K, Walkley SU, Dye JM. Herbert AS, et al. Among authors: chandran k. mBio. 2015 May 26;6(3):e00565-15. doi: 10.1128/mBio.00565-15. mBio. 2015. PMID: 26015498 Free PMC article.
Filovirus receptor NPC1 contributes to species-specific patterns of ebolavirus susceptibility in bats.
Ng M, Ndungo E, Kaczmarek ME, Herbert AS, Binger T, Kuehne AI, Jangra RK, Hawkins JA, Gifford RJ, Biswas R, Demogines A, James RM, Yu M, Brummelkamp TR, Drosten C, Wang LF, Kuhn JH, Müller MA, Dye JM, Sawyer SL, Chandran K. Ng M, et al. Among authors: chandran k. Elife. 2015 Dec 23;4:e11785. doi: 10.7554/eLife.11785. Elife. 2015. PMID: 26698106 Free PMC article.
Antibody Treatment of Ebola and Sudan Virus Infection via a Uniquely Exposed Epitope within the Glycoprotein Receptor-Binding Site.
Howell KA, Qiu X, Brannan JM, Bryan C, Davidson E, Holtsberg FW, Wec AZ, Shulenin S, Biggins JE, Douglas R, Enterlein SG, Turner HL, Pallesen J, Murin CD, He S, Kroeker A, Vu H, Herbert AS, Fusco ML, Nyakatura EK, Lai JR, Keck ZY, Foung SKH, Saphire EO, Zeitlin L, Ward AB, Chandran K, Doranz BJ, Kobinger GP, Dye JM, Aman MJ. Howell KA, et al. Among authors: chandran k. Cell Rep. 2016 May 17;15(7):1514-1526. doi: 10.1016/j.celrep.2016.04.026. Epub 2016 May 5. Cell Rep. 2016. PMID: 27160900 Free PMC article.
A "Trojan horse" bispecific-antibody strategy for broad protection against ebolaviruses.
Wec AZ, Nyakatura EK, Herbert AS, Howell KA, Holtsberg FW, Bakken RR, Mittler E, Christin JR, Shulenin S, Jangra RK, Bharrhan S, Kuehne AI, Bornholdt ZA, Flyak AI, Saphire EO, Crowe JE Jr, Aman MJ, Dye JM, Lai JR, Chandran K. Wec AZ, et al. Among authors: chandran k. Science. 2016 Oct 21;354(6310):350-354. doi: 10.1126/science.aag3267. Epub 2016 Sep 8. Science. 2016. PMID: 27608667 Free PMC article.
Antibodies from a Human Survivor Define Sites of Vulnerability for Broad Protection against Ebolaviruses.
Wec AZ, Herbert AS, Murin CD, Nyakatura EK, Abelson DM, Fels JM, He S, James RM, de La Vega MA, Zhu W, Bakken RR, Goodwin E, Turner HL, Jangra RK, Zeitlin L, Qiu X, Lai JR, Walker LM, Ward AB, Dye JM, Chandran K, Bornholdt ZA. Wec AZ, et al. Among authors: chandran k. Cell. 2017 May 18;169(5):878-890.e15. doi: 10.1016/j.cell.2017.04.037. Cell. 2017. PMID: 28525755 Free PMC article.
Immunization-Elicited Broadly Protective Antibody Reveals Ebolavirus Fusion Loop as a Site of Vulnerability.
Zhao X, Howell KA, He S, Brannan JM, Wec AZ, Davidson E, Turner HL, Chiang CI, Lei L, Fels JM, Vu H, Shulenin S, Turonis AN, Kuehne AI, Liu G, Ta M, Wang Y, Sundling C, Xiao Y, Spence JS, Doranz BJ, Holtsberg FW, Ward AB, Chandran K, Dye JM, Qiu X, Li Y, Aman MJ. Zhao X, et al. Among authors: chandran k. Cell. 2017 May 18;169(5):891-904.e15. doi: 10.1016/j.cell.2017.04.038. Cell. 2017. PMID: 28525756 Free PMC article.
509 results