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Application of pharmacogenomics and bioinformatics to exemplify the utility of human ex vivo organoculture models in the field of precision medicine.
Cowan K, Macluskie G, Finch M, Palmer CNA, Hair J, Bylesjo M, Lynagh S, Brankin P, McNeil M, Low C, Mallinson D, Gourlay EM, Child H, Cheyne L, Bunton DC. Cowan K, et al. Among authors: bunton dc. PLoS One. 2019 Dec 20;14(12):e0226564. doi: 10.1371/journal.pone.0226564. eCollection 2019. PLoS One. 2019. PMID: 31860681 Free PMC article.
Safety of medicine and the use of animals in research.
Archibald K, Baxter AD, BéruBé K, Bunton D, Clotworthy M, Coleman B, Foster CS, Hillier C, McFarlane M, Patel A, Pierscionek B, Root J, Thomas G, Tsaioun K, Wilkinson JM, Wilmut I, Wright KL. Archibald K, et al. Among authors: bunton d. Lancet. 2011 Oct 29;378(9802):e2. doi: 10.1016/S0140-6736(11)61669-3. Lancet. 2011. PMID: 22035557 No abstract available.
Discovery of N-(3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-6-yl) thiophene-2-carboximidamide as a selective inhibitor of human neuronal nitric oxide synthase (nNOS) for the treatment of pain.
Annedi SC, Maddaford SP, Mladenova G, Ramnauth J, Rakhit S, Andrews JS, Lee DK, Zhang D, Porreca F, Bunton D, Christie L. Annedi SC, et al. Among authors: bunton d. J Med Chem. 2011 Oct 27;54(20):7408-16. doi: 10.1021/jm201063u. Epub 2011 Oct 5. J Med Chem. 2011. PMID: 21923116
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