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The estrogen signaling pathway reprograms prostate cancer cell metabolism and supports proliferation and disease progression.
Lafront C, Germain L, Campolina-Silva GH, Weidmann C, Berthiaume L, Hovington H, Brisson H, Jobin C, Frégeau-Proulx L, Cotau R, Gonthier K, Lacouture A, Caron P, Ménard C, Atallah C, Riopel J, Latulippe É, Bergeron A, Toren P, Guillemette C, Pelletier M, Fradet Y, Belleannée C, Pouliot F, Lacombe L, Lévesque É, Audet-Walsh É. Lafront C, et al. Among authors: levesque e. J Clin Invest. 2024 Apr 16:e170809. doi: 10.1172/JCI170809. Online ahead of print. J Clin Invest. 2024. PMID: 38625747 Free article.
Alternative promoters control UGT2B17-dependent androgen catabolism in prostate cancer and its influence on progression.
Lévesque E, Labriet A, Hovington H, Allain ÉP, Melo-Garcia L, Rouleau M, Brisson H, Turcotte V, Caron P, Villeneuve L, Leclercq M, Droit A, Audet-Walsh E, Simonyan D, Fradet Y, Lacombe L, Guillemette C. Lévesque E, et al. Br J Cancer. 2020 Mar;122(7):1068-1076. doi: 10.1038/s41416-020-0749-2. Epub 2020 Feb 12. Br J Cancer. 2020. PMID: 32047296 Free PMC article.
Deletions of the androgen-metabolizing UGT2B genes have an effect on circulating steroid levels and biochemical recurrence after radical prostatectomy in localized prostate cancer.
Nadeau G, Bellemare J, Audet-Walsh É, Flageole C, Huang SP, Bao BY, Douville P, Caron P, Fradet Y, Lacombe L, Guillemette C, Lévesque E. Nadeau G, et al. Among authors: levesque e. J Clin Endocrinol Metab. 2011 Sep;96(9):E1550-7. doi: 10.1210/jc.2011-1049. Epub 2011 Jul 6. J Clin Endocrinol Metab. 2011. PMID: 21733997
Serum Sex Steroids as Prognostic Biomarkers in Patients Receiving Androgen Deprivation Therapy for Recurrent Prostate Cancer: A Post Hoc Analysis of the PR.7 Trial.
Toren P, Hoffman A, Ding K, Joncas FH, Turcotte V, Caron P, Pouliot F, Fradet Y, Lévesque É, Guillemette C, Klotz L. Toren P, et al. Among authors: levesque e. Clin Cancer Res. 2018 Nov 1;24(21):5305-5312. doi: 10.1158/1078-0432.CCR-18-1187. Epub 2018 Jul 18. Clin Cancer Res. 2018. PMID: 30021911 Clinical Trial.
222 results