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Development of a pharmaceutical database as an aid to the nonclinical detection of drug-induced cardiac toxicity.
J Pharmacol Toxicol Methods. 2024 Apr 16:107507. doi: 10.1016/j.vascn.2024.107507. Online ahead of print.
J Pharmacol Toxicol Methods. 2024.
PMID: 38636673
Free article.
An evaluation of the utility of LVdP/dt40, QA interval, LVdP/dtmin and Tau as indicators of drug-induced changes in contractility and lusitropy in dogs.
Pugsley MK, Guth B, Chiang AY, Doyle JM, Engwall M, Guillon JM, Hoffmann PK, Koerner JE, Mittelstadt SW, Pierson JB, Rossman EI, Sarazan DR, Parish ST.
Pugsley MK, et al. Among authors: hoffmann pk.
J Pharmacol Toxicol Methods. 2017 May-Jun;85:1-21. doi: 10.1016/j.vascn.2017.01.002. Epub 2017 Jan 5.
J Pharmacol Toxicol Methods. 2017.
PMID: 28065821
Free article.
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Nonclinical safety biomarkers of drug-induced vascular injury: current status and blueprint for the future.
Mikaelian I, Cameron M, Dalmas DA, Enerson BE, Gonzalez RJ, Guionaud S, Hoffmann PK, King NM, Lawton MP, Scicchitano MS, Smith HW, Thomas RA, Weaver JL, Zabka TS; Vascular Injury Working Group of the Predictive Safety Consortium.
Mikaelian I, et al. Among authors: hoffmann pk.
Toxicol Pathol. 2014 Jun;42(4):635-57. doi: 10.1177/0192623314525686. Epub 2014 Apr 28.
Toxicol Pathol. 2014.
PMID: 24777748
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Cardiac Safety Implications of hNav1.5 Blockade and a Framework for Pre-Clinical Evaluation.
Erdemli G, Kim AM, Ju H, Springer C, Penland RC, Hoffmann PK.
Erdemli G, et al. Among authors: hoffmann pk.
Front Pharmacol. 2012 Jan 26;3:6. doi: 10.3389/fphar.2012.00006. eCollection 2012.
Front Pharmacol. 2012.
PMID: 22303294
Free PMC article.
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A HESI consortium approach to assess the human predictive value of non-clinical repolarization assays.
Trepakova ES, Koerner J, Pettit SD, Valentin JP; HESI Pro-Arrhythmia Committee.
Trepakova ES, et al.
J Pharmacol Toxicol Methods. 2009 Jul-Aug;60(1):45-50. doi: 10.1016/j.vascn.2009.05.002. Epub 2009 May 9.
J Pharmacol Toxicol Methods. 2009.
PMID: 19439186
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Adverse effects of dipeptidyl peptidases 8 and 9 inhibition in rodents revisited.
Burkey BF, Hoffmann PK, Hassiepen U, Trappe J, Juedes M, Foley JE.
Burkey BF, et al. Among authors: hoffmann pk.
Diabetes Obes Metab. 2008 Nov;10(11):1057-61. doi: 10.1111/j.1463-1326.2008.00860.x. Epub 2008 Apr 17.
Diabetes Obes Metab. 2008.
PMID: 18422675
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