Linderman JJ - Search Results

1

Optimizing Solid Tumor Treatment with Antibody-drug Conjugates Using Agent-Based Modeling: Considering the Role of a Carrier Dose and Payload Class.

Calopiz MC, Linderman JJ, Thurber GM. Calopiz MC, et al. Among authors: linderman jj. Pharm Res. 2024 May 28. doi: 10.1007/s11095-024-03715-0. Online ahead of print. Pharm Res. 2024. PMID: 38806889

2

In vivo Auto-tuning of Antibody-Drug Conjugate Delivery for Effective Immunotherapy using High-Avidity, Low-Affinity Antibodies.

Kopp A, Dong S, Kwon H, Wang T, Desai AA, Linderman JJ, Tessier P, Thurber GM. Kopp A, et al. Among authors: linderman jj. bioRxiv [Preprint]. 2024 Apr 10:2024.04.06.588433. doi: 10.1101/2024.04.06.588433. bioRxiv. 2024. PMID: 38645231 Free PMC article. Preprint.

3

Characterizing heterogeneous single-cell dose responses computationally and experimentally using threshold inhibition surfaces and dose-titration assays.

Kinnunen PC, Humphries BA, Luker GD, Luker KE, Linderman JJ. Kinnunen PC, et al. Among authors: linderman jj. NPJ Syst Biol Appl. 2024 Apr 18;10(1):42. doi: 10.1038/s41540-024-00369-x. NPJ Syst Biol Appl. 2024. PMID: 38637530 Free PMC article.

4

Optimizing tuberculosis treatment efficacy: Comparing the standard regimen with Moxifloxacin-containing regimens.

Budak M, Cicchese JM, Maiello P, Borish HJ, White AG, Chishti HB, Tomko J, Frye LJ, Fillmore D, Kracinovsky K, Sakal J, Scanga CA, Lin PL, Dartois V, Linderman JJ, Flynn JL, Kirschner DE. Budak M, et al. Among authors: linderman jj. PLoS Comput Biol. 2023 Jun 15;19(6):e1010823. doi: 10.1371/journal.pcbi.1010823. eCollection 2023 Jun. PLoS Comput Biol. 2023. PMID: 37319311 Free PMC article.

5

Concomitant immunity to M. tuberculosis infection.

Joslyn LR, Flynn JL, Kirschner DE, Linderman JJ. Joslyn LR, et al. Among authors: linderman jj. Sci Rep. 2022 Dec 1;12(1):20731. doi: 10.1038/s41598-022-24516-8. Sci Rep. 2022. PMID: 36456599 Free PMC article.

6

Pharmacokinetics and Pharmacodynamics of TAK-164 Antibody Drug Conjugate Coadministered with Unconjugated Antibody.

Menezes B, Khera E, Calopiz M, Smith MD, Ganno ML, Cilliers C, Abu-Yousif AO, Linderman JJ, Thurber GM. Menezes B, et al. Among authors: linderman jj. AAPS J. 2022 Oct 7;24(6):107. doi: 10.1208/s12248-022-00756-4. AAPS J. 2022. PMID: 36207468 Free PMC article.

7

Computational modeling implicates protein scaffolding in p38 regulation of Akt.

Kinnunen PC, Luker GD, Luker KE, Linderman JJ. Kinnunen PC, et al. Among authors: linderman jj. J Theor Biol. 2022 Dec 21;555:111294. doi: 10.1016/j.jtbi.2022.111294. Epub 2022 Oct 1. J Theor Biol. 2022. PMID: 36195198 Free PMC article.

8

Co-optimization of therapeutic antibody affinity and specificity using machine learning models that generalize to novel mutational space.

Makowski EK, Kinnunen PC, Huang J, Wu L, Smith MD, Wang T, Desai AA, Streu CN, Zhang Y, Zupancic JM, Schardt JS, Linderman JJ, Tessier PM. Makowski EK, et al. Among authors: linderman jj. Nat Commun. 2022 Jul 1;13(1):3788. doi: 10.1038/s41467-022-31457-3. Nat Commun. 2022. PMID: 35778381 Free PMC article.

9

Computational methods for characterizing and learning from heterogeneous cell signaling data.

Kinnunen PC, Luker KE, Luker GD, Linderman JJ. Kinnunen PC, et al. Among authors: linderman jj. Curr Opin Syst Biol. 2021 Jun;26:98-108. doi: 10.1016/j.coisb.2021.04.009. Epub 2021 May 4. Curr Opin Syst Biol. 2021. PMID: 35647414 Free PMC article.

10

A virtual host model of Mycobacterium tuberculosis infection identifies early immune events as predictive of infection outcomes.

Joslyn LR, Linderman JJ, Kirschner DE. Joslyn LR, et al. Among authors: linderman jj. J Theor Biol. 2022 Apr 21;539:111042. doi: 10.1016/j.jtbi.2022.111042. Epub 2022 Jan 31. J Theor Biol. 2022. PMID: 35114195 Free PMC article.

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