LaPointe P - Search Results

1

Hsp90 inhibition leads to an increase in surface expression of multiple immunological receptors in cancer cells.

Wickenberg M, Mercier R, Yap M, Walker J, Baker K, LaPointe P. Wickenberg M, et al. Among authors: lapointe p. Front Mol Biosci. 2024 Apr 5;11:1334876. doi: 10.3389/fmolb.2024.1334876. eCollection 2024. Front Mol Biosci. 2024. PMID: 38645275 Free PMC article.

2

A mutation in the catalytic loop of Hsp90 specifically impairs ATPase stimulation by Aha1p, but not Hch1p.

Horvat NK, Armstrong H, Lee BL, Mercier R, Wolmarans A, Knowles J, Spyracopoulos L, LaPointe P. Horvat NK, et al. Among authors: lapointe p. J Mol Biol. 2014 Jun 12;426(12):2379-92. doi: 10.1016/j.jmb.2014.04.002. Epub 2014 Apr 12. J Mol Biol. 2014. PMID: 24726918

3

Aha-type co-chaperones: the alpha or the omega of the Hsp90 ATPase cycle?

LaPointe P, Mercier R, Wolmarans A. LaPointe P, et al. Biol Chem. 2020 Mar 26;401(4):423-434. doi: 10.1515/hsz-2019-0341. Biol Chem. 2020. PMID: 31782942 Free article. Review.

4

The role of cellular proteostasis in antitumor immunity.

Mercier R, LaPointe P. Mercier R, et al. Among authors: lapointe p. J Biol Chem. 2022 May;298(5):101930. doi: 10.1016/j.jbc.2022.101930. Epub 2022 Apr 11. J Biol Chem. 2022. PMID: 35421375 Free PMC article. Review.

5

Hsp90 mutants with distinct defects provide novel insights into cochaperone regulation of the folding cycle.

Mercier R, Yama D, LaPointe P, Johnson JL. Mercier R, et al. Among authors: lapointe p. PLoS Genet. 2023 May 25;19(5):e1010772. doi: 10.1371/journal.pgen.1010772. eCollection 2023 May. PLoS Genet. 2023. PMID: 37228112 Free PMC article.

6

The co-chaperone Hch1 regulates Hsp90 function differently than its homologue Aha1 and confers sensitivity to yeast to the Hsp90 inhibitor NVP-AUY922.

Armstrong H, Wolmarans A, Mercier R, Mai B, LaPointe P. Armstrong H, et al. Among authors: lapointe p. PLoS One. 2012;7(11):e49322. doi: 10.1371/journal.pone.0049322. Epub 2012 Nov 14. PLoS One. 2012. PMID: 23166640 Free PMC article.

7

The conserved NxNNWHW motif in Aha-type co-chaperones modulates the kinetics of Hsp90 ATPase stimulation.

Mercier R, Wolmarans A, Schubert J, Neuweiler H, Johnson JL, LaPointe P. Mercier R, et al. Among authors: lapointe p. Nat Commun. 2019 Mar 20;10(1):1273. doi: 10.1038/s41467-019-09299-3. Nat Commun. 2019. PMID: 30894538 Free PMC article.

8

Regulation of RNA interference by Hsp90 is an evolutionarily conserved process.

Wang Y, Mercier R, Hobman TC, LaPointe P. Wang Y, et al. Among authors: lapointe p. Biochim Biophys Acta. 2013 Dec;1833(12):2673-2681. doi: 10.1016/j.bbamcr.2013.06.017. Epub 2013 Jul 1. Biochim Biophys Acta. 2013. PMID: 23827255 Free article.

9

The activity of the Drosophila Vestigial protein is modified by Scalloped-dependent phosphorylation.

Pimmett VL, Deng H, Haskins JA, Mercier RJ, LaPointe P, Simmonds AJ. Pimmett VL, et al. Among authors: lapointe p. Dev Biol. 2017 May 1;425(1):58-69. doi: 10.1016/j.ydbio.2017.03.013. Epub 2017 Mar 18. Dev Biol. 2017. PMID: 28322734 Free article.

10

The ER chaperone calnexin controls mitochondrial positioning and respiration.

Gutiérrez T, Qi H, Yap MC, Tahbaz N, Milburn LA, Lucchinetti E, Lou PH, Zaugg M, LaPointe PG, Mercier P, Overduin M, Bischof H, Burgstaller S, Malli R, Ballanyi K, Shuai J, Simmen T. Gutiérrez T, et al. Among authors: lapointe pg. Sci Signal. 2020 Jun 30;13(638):eaax6660. doi: 10.1126/scisignal.aax6660. Sci Signal. 2020. PMID: 32606038

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