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Membrane-bound O-acyltransferase 7 (MBOAT7) shapes lysosomal lipid homeostasis and function to control alcohol-associated liver injury.
Varadharajan V, Ramachandiran I, Massey WJ, Jain R, Banerjee R, Horak AJ, McMullen MR, Huang E, Bellar A, Lorkowski SW, Gulshan K, Helsley RN, James I, Pathak V, Dasarathy J, Welch N, Dasarathy S, Streem D, Reizes O, Allende DS, Smith JD, Simcox J, Nagy LE, Brown JM. Varadharajan V, et al. Among authors: lorkowski sw. Elife. 2024 Apr 22;12:RP92243. doi: 10.7554/eLife.92243. Elife. 2024. PMID: 38648183 Free PMC article.
Membrane Bound O-Acyltransferase 7 (MBOAT7) Shapes Lysosomal Lipid Homeostasis and Function to Control Alcohol-Associated Liver Injury.
Varadharajan V, Ramachandiran L, Massey WJ, Jain R, Banerjee R, Horak AJ, McMullen MR, Huang E, Bellar A, Lorkowski SW, Guilshan K, Helsley RN, James I, Pathak V, Dasarathy J, Welch N, Dasarathy S, Streem D, Reizes O, Allende DS, Smith JD, Simcox J, Nagy LE, Brown JM. Varadharajan V, et al. Among authors: lorkowski sw. bioRxiv [Preprint]. 2024 Jan 10:2023.09.26.559533. doi: 10.1101/2023.09.26.559533. bioRxiv. 2024. PMID: 37808828 Free PMC article. Updated. Preprint.
HDL Is Not Dead Yet.
Lorkowski SW, Smith JD. Lorkowski SW, et al. Biomedicines. 2022 Jan 7;10(1):128. doi: 10.3390/biomedicines10010128. Biomedicines. 2022. PMID: 35052806 Free PMC article. Review.
Uptake of high-density lipoprotein by scavenger receptor class B type 1 is associated with prostate cancer proliferation and tumor progression in mice.
Traughber CA, Opoku E, Brubaker G, Major J, Lu H, Lorkowski SW, Neumann C, Hardaway A, Chung YM, Gulshan K, Sharifi N, Brown JM, Smith JD. Traughber CA, et al. Among authors: lorkowski sw. J Biol Chem. 2020 Jun 12;295(24):8252-8261. doi: 10.1074/jbc.RA120.013694. Epub 2020 May 1. J Biol Chem. 2020. PMID: 32358065 Free PMC article.
Dysregulated cellular redox status during hyperammonemia causes mitochondrial dysfunction and senescence by inhibiting sirtuin-mediated deacetylation.
Mishra S, Welch N, Karthikeyan M, Bellar A, Musich R, Singh SS, Zhang D, Sekar J, Attaway AH, Chelluboyina AK, Lorkowski SW, Roychowdhury S, Li L, Willard B, Smith JD, Hoppel CL, Vachharajani V, Kumar A, Dasarathy S. Mishra S, et al. Among authors: lorkowski sw. Aging Cell. 2023 Jul;22(7):e13852. doi: 10.1111/acel.13852. Epub 2023 Apr 26. Aging Cell. 2023. PMID: 37101412 Free PMC article.
HDL flux is higher in patients with nonalcoholic fatty liver disease.
McCullough A, Previs SF, Dasarathy J, Lee K, Osme A, Kim C, Ilchenko S, Lorkowski SW, Smith JD, Dasarathy S, Kasumov T. McCullough A, et al. Among authors: lorkowski sw. Am J Physiol Endocrinol Metab. 2019 Nov 1;317(5):E852-E862. doi: 10.1152/ajpendo.00193.2019. Epub 2019 Sep 10. Am J Physiol Endocrinol Metab. 2019. PMID: 31503515 Free PMC article.
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