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JAK-STAT signaling maintains homeostasis in T cells and macrophages.
Fortelny N, Farlik M, Fife V, Gorki AD, Lassnig C, Maurer B, Meissl K, Dolezal M, Boccuni L, Ravi Sundar Jose Geetha A, Akagha MJ, Karjalainen A, Shoebridge S, Farhat A, Mann U, Jain R, Tikoo S, Zila N, Esser-Skala W, Krausgruber T, Sitnik K, Penz T, Hladik A, Suske T, Zahalka S, Senekowitsch M, Barreca D, Halbritter F, Macho-Maschler S, Weninger W, Neubauer HA, Moriggl R, Knapp S, Sexl V, Strobl B, Decker T, Müller M, Bock C. Fortelny N, et al. Among authors: strobl b. Nat Immunol. 2024 May;25(5):847-859. doi: 10.1038/s41590-024-01804-1. Epub 2024 Apr 24. Nat Immunol. 2024. PMID: 38658806 Free PMC article.
The good and the bad faces of STAT1 in solid tumours.
Meissl K, Macho-Maschler S, Müller M, Strobl B. Meissl K, et al. Among authors: strobl b. Cytokine. 2017 Jan;89:12-20. doi: 10.1016/j.cyto.2015.11.011. Epub 2015 Nov 26. Cytokine. 2017. PMID: 26631912 Free article. Review.
Trained immunity of alveolar macrophages requires metabolic rewiring and type 1 interferon signaling.
Zahalka S, Starkl P, Watzenboeck ML, Farhat A, Radhouani M, Deckert F, Hladik A, Lakovits K, Oberndorfer F, Lassnig C, Strobl B, Klavins K, Matsushita M, Sanin DE, Grzes KM, Pearce EJ, Gorki AD, Knapp S. Zahalka S, et al. Among authors: strobl b. Mucosal Immunol. 2022 May;15(5):896-907. doi: 10.1038/s41385-022-00528-5. Epub 2022 Jul 18. Mucosal Immunol. 2022. PMID: 35856089 Free PMC article.
TYK2: An Upstream Kinase of STATs in Cancer.
Wöss K, Simonović N, Strobl B, Macho-Maschler S, Müller M. Wöss K, et al. Among authors: strobl b. Cancers (Basel). 2019 Nov 5;11(11):1728. doi: 10.3390/cancers11111728. Cancers (Basel). 2019. PMID: 31694222 Free PMC article. Review.
TYK2 in Tumor Immunosurveillance.
Karjalainen A, Shoebridge S, Krunic M, Simonović N, Tebb G, Macho-Maschler S, Strobl B, Müller M. Karjalainen A, et al. Among authors: strobl b. Cancers (Basel). 2020 Jan 8;12(1):150. doi: 10.3390/cancers12010150. Cancers (Basel). 2020. PMID: 31936322 Free PMC article. Review.
STAT1 Isoforms Differentially Regulate NK Cell Maturation and Anti-tumor Activity.
Meissl K, Simonović N, Amenitsch L, Witalisz-Siepracka A, Klein K, Lassnig C, Puga A, Vogl C, Poelzl A, Bosmann M, Dohnal A, Sexl V, Müller M, Strobl B. Meissl K, et al. Among authors: strobl b. Front Immunol. 2020 Sep 11;11:2189. doi: 10.3389/fimmu.2020.02189. eCollection 2020. Front Immunol. 2020. PMID: 33042133 Free PMC article.
Lipocalin 2 modulates dendritic cell activity and shapes immunity to influenza in a microbiome dependent manner.
Watzenboeck ML, Drobits B, Zahalka S, Gorki AD, Farhat A, Quattrone F, Hladik A, Lakovits K, Richard GM, Lederer T, Strobl B, Versteeg GA, Boon L, Starkl P, Knapp S. Watzenboeck ML, et al. Among authors: strobl b. PLoS Pathog. 2021 Apr 27;17(4):e1009487. doi: 10.1371/journal.ppat.1009487. eCollection 2021 Apr. PLoS Pathog. 2021. PMID: 33905460 Free PMC article.
Oncogenic TYK2 P760L kinase is effectively targeted by combinatorial TYK2, mTOR and CDK4/6 kinase blockade.
Woess K, Macho-Maschler S, Van Ingen Schenau DS, Butler M, Lassnig C, Valcanover D, Poelzl A, Meissl K, Maurer B, Brandstoetter T, Vogl C, Koren A, Kubicek S, Orlova A, Moriggl R, Strobl B, Sexl V, Van Leeuwen FN, Kuiper RP, Mueller M. Woess K, et al. Among authors: strobl b. Haematologica. 2023 Apr 1;108(4):993-1005. doi: 10.3324/haematol.2021.279848. Haematologica. 2023. PMID: 35021603 Free PMC article.
126 results