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Tumorigenesis driven by the BRAFV600E oncoprotein requires secondary mutations that overcome its feedback inhibition of migration and invasion.
Gadal S, Boyer JA, Roy SF, Outmezguine NA, Sharma M, Li H, Fan N, Chan E, Romin Y, Barlas A, Chang Q, Pancholi P, Timaul NM, Overholtzer M, Yaeger R, Manova-Todorova K, de Stanchina E, Bosenberg M, Rosen N. Gadal S, et al. Among authors: overholtzer m. bioRxiv [Preprint]. 2024 Apr 20:2023.11.21.568071. doi: 10.1101/2023.11.21.568071. bioRxiv. 2024. PMID: 38659913 Free PMC article. Preprint.
WNK1 enforces macrophage lineage fidelity.
Trzeciak AJ, Rojas WS, Liu ZL, Krebs AS, Wang Z, Saavedra PHV, Miranda IC, Lipshutz A, Xie J, Huang CL, Overholtzer M, Glickman MS, Parkhurst CN, Vierbuchen T, Lucas CD, Perry JSA. Trzeciak AJ, et al. Among authors: overholtzer m. bioRxiv [Preprint]. 2023 Apr 28:2023.04.26.538482. doi: 10.1101/2023.04.26.538482. bioRxiv. 2023. PMID: 37383948 Free PMC article. Preprint.
Ultrasmall Nanoparticle Delivery of Doxorubicin Improves Therapeutic Index for High-Grade Glioma.
Aragon-Sanabria V, Aditya A, Zhang L, Chen F, Yoo B, Cao T, Madajewski B, Lee R, Turker MZ, Ma K, Monette S, Chen P, Wu J, Ruan S, Overholtzer M, Zanzonico P, Rudin CM, Brennan C, Wiesner U, Bradbury MS. Aragon-Sanabria V, et al. Among authors: overholtzer m. Clin Cancer Res. 2022 Jul 1;28(13):2938-2952. doi: 10.1158/1078-0432.CCR-21-4053. Clin Cancer Res. 2022. PMID: 35499557 Free PMC article.
Leucine retention in lysosomes is regulated by starvation.
Bandyopadhyay U, Todorova P, Pavlova NN, Tada Y, Thompson CB, Finley LWS, Overholtzer M. Bandyopadhyay U, et al. Among authors: overholtzer m. Proc Natl Acad Sci U S A. 2022 Feb 8;119(6):e2114912119. doi: 10.1073/pnas.2114912119. Proc Natl Acad Sci U S A. 2022. PMID: 35105808 Free PMC article.
Cell death leaves a new TRAIL.
Overholtzer M. Overholtzer M. J Cell Biol. 2021 Nov 1;220(11):e202109018. doi: 10.1083/jcb.202109018. Epub 2021 Oct 13. J Cell Biol. 2021. PMID: 34643655 Free PMC article.
Entosis is induced by ultraviolet radiation.
Chen R, Ram A, Albeck JG, Overholtzer M. Chen R, et al. Among authors: overholtzer m. iScience. 2021 Jul 24;24(8):102902. doi: 10.1016/j.isci.2021.102902. eCollection 2021 Aug 20. iScience. 2021. PMID: 34401679 Free PMC article.
89 results