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Page 1
Mitochondria inside acute myeloid leukemia cells hydrolyze ATP to resist chemotherapy.
Hagen JT, Montgomery MM, Aruleba RT, Chrest BR, Green TD, Kassai M, Zeczycki TN, Schmidt CA, Bhowmick D, Tan SF, Feith DJ, Chalfant CE, Loughran TP Jr, Liles D, Minden MD, Schimmer AD, Cabot MC, Mclung JM, Fisher-Wellman KH. Hagen JT, et al. bioRxiv [Preprint]. 2024 Apr 15:2024.04.12.589110. doi: 10.1101/2024.04.12.589110. bioRxiv. 2024. PMID: 38659944 Free PMC article. Preprint.
Simultaneous Inhibition of Ceramide Hydrolysis and Glycosylation Synergizes to Corrupt Mitochondrial Respiration and Signal Caspase Driven Cell Death in Drug-Resistant Acute Myeloid Leukemia.
Fisher-Wellman KH, Kassai M, Hagen JT, Neufer PD, Kester M, Loughran TP Jr, Chalfant CE, Feith DJ, Tan SF, Fox TE, Ung J, Fabrias G, Abad JL, Sharma A, Golla U, Claxton DF, Shaw JJP, Bhowmick D, Cabot MC. Fisher-Wellman KH, et al. Among authors: hagen jt. Cancers (Basel). 2023 Mar 21;15(6):1883. doi: 10.3390/cancers15061883. Cancers (Basel). 2023. PMID: 36980769 Free PMC article.
Alterations in sphingolipid composition and mitochondrial bioenergetics represent synergistic therapeutic vulnerabilities linked to multidrug resistance in leukemia.
Fisher-Wellman KH, Hagen JT, Kassai M, Kao LP, Nelson MAM, McLaughlin KL, Coalson HS, Fox TE, Tan SF, Feith DJ, Kester M, Loughran TP Jr, Claxton DF, Cabot MC. Fisher-Wellman KH, et al. Among authors: hagen jt. FASEB J. 2022 Jan;36(1):e22094. doi: 10.1096/fj.202101194RRR. FASEB J. 2022. PMID: 34888943 Free PMC article.
Intrinsic OXPHOS limitations underlie cellular bioenergetics in leukemia.
Nelson MA, McLaughlin KL, Hagen JT, Coalson HS, Schmidt C, Kassai M, Kew KA, McClung JM, Neufer PD, Brophy P, Vohra NA, Liles D, Cabot MC, Fisher-Wellman KH. Nelson MA, et al. Among authors: hagen jt. Elife. 2021 Jun 16;10:e63104. doi: 10.7554/eLife.63104. Elife. 2021. PMID: 34132194 Free PMC article.
Bioenergetic Phenotyping of DEN-Induced Hepatocellular Carcinoma Reveals a Link Between Adenylate Kinase Isoform Expression and Reduced Complex I-Supported Respiration.
McLaughlin KL, Nelson MAM, Coalson HS, Hagen JT, Montgomery MM, Wooten AR, Zeczycki TN, Vohra NA, Fisher-Wellman KH. McLaughlin KL, et al. Among authors: hagen jt. Front Oncol. 2022 Jun 8;12:919880. doi: 10.3389/fonc.2022.919880. eCollection 2022. Front Oncol. 2022. PMID: 35756609 Free PMC article.
Intrinsic adaptations in OXPHOS power output and reduced tumorigenicity characterize doxorubicin resistant ovarian cancer cells.
Hagen JT, Montgomery MM, Biagioni EM, Krassovskaia P, Jevtovic F, Shookster D, Sharma U, Tung K, Broskey NT, May L, Huang H, Brault JJ, Neufer PD, Cabot MC, Fisher-Wellman KH. Hagen JT, et al. Biochim Biophys Acta Bioenerg. 2022 Nov 1;1863(8):148915. doi: 10.1016/j.bbabio.2022.148915. Epub 2022 Sep 2. Biochim Biophys Acta Bioenerg. 2022. PMID: 36058252 Free PMC article.
The alpha-1A adrenergic receptor regulates mitochondrial oxidative metabolism in the mouse heart.
Sandroni PB, Schroder MA, Hawkins HT, Bailon JD, Huang W, Hagen JT, Montgomery M, Hong SJ, Chin AL, Zhang J, Rodrigo MC, Kim B, Simpson PC, Schisler JC, Ellis JM, Fisher-Wellman KH, Jensen BC. Sandroni PB, et al. Among authors: hagen jt. J Mol Cell Cardiol. 2024 Feb;187:101-117. doi: 10.1016/j.yjmcc.2023.12.003. Epub 2024 Feb 6. J Mol Cell Cardiol. 2024. PMID: 38331556
12 results