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The MYCN 5' UTR as a therapeutic target in neuroblastoma.
Volegova MP, Brown LE, Banerjee U, Dries R, Sharma B, Kennedy A, Porco JA Jr, George RE. Volegova MP, et al. Among authors: brown le. Cell Rep. 2024 May 28;43(5):114134. doi: 10.1016/j.celrep.2024.114134. Epub 2024 Apr 23. Cell Rep. 2024. PMID: 38662542 Free article.
Rocaglates Induce Gain-of-Function Alterations to eIF4A and eIF4F.
Chu J, Zhang W, Cencic R, O'Connor PBF, Robert F, Devine WG, Selznick A, Henkel T, Merrick WC, Brown LE, Baranov PV, Porco JA Jr, Pelletier J. Chu J, et al. Among authors: brown le. Cell Rep. 2020 Feb 25;30(8):2481-2488.e5. doi: 10.1016/j.celrep.2020.02.002. Cell Rep. 2020. PMID: 32101697 Free PMC article.
Oxo-aglaiastatin-Mediated Inhibition of Translation Initiation.
Itoua Maïga R, Cencic R, Chu J, Waller DD, Brown LE, Devine WG, Zhang W, Sebag M, Porco JA Jr, Pelletier J. Itoua Maïga R, et al. Among authors: brown le. Sci Rep. 2019 Feb 4;9(1):1265. doi: 10.1038/s41598-018-37666-5. Sci Rep. 2019. PMID: 30718665 Free PMC article.
Amidino-Rocaglates: A Potent Class of eIF4A Inhibitors.
Chu J, Zhang W, Cencic R, Devine WG, Beglov D, Henkel T, Brown LE, Vajda S, Porco JA Jr, Pelletier J. Chu J, et al. Among authors: brown le. Cell Chem Biol. 2019 Nov 21;26(11):1586-1593.e3. doi: 10.1016/j.chembiol.2019.08.008. Epub 2019 Sep 10. Cell Chem Biol. 2019. PMID: 31519508 Free PMC article.
Inhibiting the oncogenic translation program is an effective therapeutic strategy in multiple myeloma.
Manier S, Huynh D, Shen YJ, Zhou J, Yusufzai T, Salem KZ, Ebright RY, Shi J, Park J, Glavey SV, Devine WG, Liu CJ, Leleu X, Quesnel B, Roche-Lestienne C, Snyder JK, Brown LE, Gray N, Bradner J, Whitesell L, Porco JA Jr, Ghobrial IM. Manier S, et al. Among authors: brown le. Sci Transl Med. 2017 May 10;9(389):eaal2668. doi: 10.1126/scitranslmed.aal2668. Sci Transl Med. 2017. PMID: 28490664 Free PMC article.
537 results