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Group 3 medulloblastoma transcriptional networks collapse under domain specific EP300/CBP inhibition.
Shendy NAM, Bikowitz M, Sigua LH, Zhang Y, Mercier A, Khashana Y, Nance S, Liu Q, Delahunty IM, Robinson S, Goel V, Rees MG, Ronan MA, Wang T, Kocak M, Roth JA, Wang Y, Freeman BB, Orr BA, Abraham BJ, Roussel MF, Schonbrunn E, Qi J, Durbin AD. Shendy NAM, et al. Among authors: durbin ad. Nat Commun. 2024 Apr 25;15(1):3483. doi: 10.1038/s41467-024-47102-0. Nat Commun. 2024. PMID: 38664416 Free PMC article.
EP300 Selectively Controls the Enhancer Landscape of MYCN-Amplified Neuroblastoma.
Durbin AD, Wang T, Wimalasena VK, Zimmerman MW, Li D, Dharia NV, Mariani L, Shendy NAM, Nance S, Patel AG, Shao Y, Mundada M, Maxham L, Park PMC, Sigua LH, Morita K, Conway AS, Robichaud AL, Perez-Atayde AR, Bikowitz MJ, Quinn TR, Wiest O, Easton J, Schönbrunn E, Bulyk ML, Abraham BJ, Stegmaier K, Look AT, Qi J. Durbin AD, et al. Cancer Discov. 2022 Mar 1;12(3):730-751. doi: 10.1158/2159-8290.CD-21-0385. Cancer Discov. 2022. PMID: 34772733 Free PMC article.
Using Chemical Epigenetics to Target Cancer.
Wimalasena VK, Wang T, Sigua LH, Durbin AD, Qi J. Wimalasena VK, et al. Among authors: durbin ad. Mol Cell. 2020 Jun 18;78(6):1086-1095. doi: 10.1016/j.molcel.2020.04.023. Epub 2020 May 13. Mol Cell. 2020. PMID: 32407673 Free PMC article. Review.
A CRISPR-drug perturbational map for identifying compounds to combine with commonly used chemotherapeutics.
Lee HM, Wright WC, Pan M, Low J, Currier D, Fang J, Singh S, Nance S, Delahunty I, Kim Y, Chapple RH, Zhang Y, Liu X, Steele JA, Qi J, Pruett-Miller SM, Easton J, Chen T, Yang J, Durbin AD, Geeleher P. Lee HM, et al. Among authors: durbin ad. Nat Commun. 2023 Nov 13;14(1):7332. doi: 10.1038/s41467-023-43134-0. Nat Commun. 2023. PMID: 37957169 Free PMC article.
Collateral lethality between HDAC1 and HDAC2 exploits cancer-specific NuRD complex vulnerabilities.
Zhang Y, Remillard D, Onubogu U, Karakyriakou B, Asiaban JN, Ramos AR, Bowland K, Bishop TR, Barta PA, Nance S, Durbin AD, Ott CJ, Janiszewska M, Cravatt BF, Erb MA. Zhang Y, et al. Among authors: durbin ad. Nat Struct Mol Biol. 2023 Aug;30(8):1160-1171. doi: 10.1038/s41594-023-01041-4. Epub 2023 Jul 24. Nat Struct Mol Biol. 2023. PMID: 37488358 Free PMC article.
MYC Drives a Subset of High-Risk Pediatric Neuroblastomas and Is Activated through Mechanisms Including Enhancer Hijacking and Focal Enhancer Amplification.
Zimmerman MW, Liu Y, He S, Durbin AD, Abraham BJ, Easton J, Shao Y, Xu B, Zhu S, Zhang X, Li Z, Weichert-Leahey N, Young RA, Zhang J, Look AT. Zimmerman MW, et al. Among authors: durbin ad. Cancer Discov. 2018 Mar;8(3):320-335. doi: 10.1158/2159-8290.CD-17-0993. Epub 2017 Dec 28. Cancer Discov. 2018. PMID: 29284669 Free PMC article.
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