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Probing the CRL4DCAF12 interactions with MAGEA3 and CCT5 di-Glu C-terminal degrons.
Righetto GL, Yin Y, Duda DM, Vu V, Szewczyk MM, Zeng H, Li Y, Loppnau P, Mei T, Li YY, Seitova A, Patrick AN, Brazeau JF, Chaudhry C, Barsyte-Lovejoy D, Santhakumar V, Halabelian L. Righetto GL, et al. Among authors: patrick an. PNAS Nexus. 2024 Apr 10;3(4):pgae153. doi: 10.1093/pnasnexus/pgae153. eCollection 2024 Apr. PNAS Nexus. 2024. PMID: 38665159 Free PMC article.
Structural and mechanistic insights into the inhibition of respiratory syncytial virus polymerase by a non-nucleoside inhibitor.
Yu X, Abeywickrema P, Bonneux B, Behera I, Anson B, Jacoby E, Fung A, Adhikary S, Bhaumik A, Carbajo RJ, De Bruyn S, Miller R, Patrick A, Pham Q, Piassek M, Verheyen N, Shareef A, Sutto-Ortiz P, Ysebaert N, Van Vlijmen H, Jonckers THM, Herschke F, McLellan JS, Decroly E, Fearns R, Grosse S, Roymans D, Sharma S, Rigaux P, Jin Z. Yu X, et al. Commun Biol. 2023 Oct 21;6(1):1074. doi: 10.1038/s42003-023-05451-4. Commun Biol. 2023. PMID: 37865687 Free PMC article.
JNJ-7184, a Respiratory Syncytial Virus inhibitor targeting the connector domain of the viral polymerase.
Bonneux B, Shareef A, Tcherniuk S, Anson B, de Bruyn S, Verheyen N, Thys K, Conceição-Neto N, Van Ginderen M, Kwanten L, Ysebaert N, Vranckx L, Peeters E, Lanckacker E, Gallup JM, Sitthicharoenchai P, Alnajjar S, Ackermann MR, Adhikari S, Bhaumik A, Patrick A, Fung A, Sutto-Ortiz P, Decroly E, Mason SW, Lançois D, Deval J, Jin Z, Eléouët JF, Fearns R, Koul A, Roymans D, Rigaux P, Herschke F. Bonneux B, et al. Antiviral Res. 2024 May 19:105907. doi: 10.1016/j.antiviral.2024.105907. Online ahead of print. Antiviral Res. 2024. PMID: 38772503
The SIX1-EYA transcriptional complex as a therapeutic target in cancer.
Blevins MA, Towers CG, Patrick AN, Zhao R, Ford HL. Blevins MA, et al. Among authors: patrick an. Expert Opin Ther Targets. 2015 Feb;19(2):213-25. doi: 10.1517/14728222.2014.978860. Epub 2015 Jan 2. Expert Opin Ther Targets. 2015. PMID: 25555392 Free PMC article. Review.
Allosteric inhibitors of the Eya2 phosphatase are selective and inhibit Eya2-mediated cell migration.
Krueger AB, Drasin DJ, Lea WA, Patrick AN, Patnaik S, Backos DS, Matheson CJ, Hu X, Barnaeva E, Holliday MJ, Blevins MA, Robin TP, Eisenmesser EZ, Ferrer M, Simeonov A, Southall N, Reigan P, Marugan J, Ford HL, Zhao R. Krueger AB, et al. Among authors: patrick an. J Biol Chem. 2014 Jun 6;289(23):16349-61. doi: 10.1074/jbc.M114.566729. Epub 2014 Apr 22. J Biol Chem. 2014. PMID: 24755226 Free PMC article.
CDK6 binds and promotes the degradation of the EYA2 protein.
Kohrt D, Crary J, Zimmer M, Patrick AN, Ford HL, Hinds PW, Grossel MJ. Kohrt D, et al. Among authors: patrick an. Cell Cycle. 2014;13(1):62-71. doi: 10.4161/cc.26755. Epub 2013 Oct 12. Cell Cycle. 2014. PMID: 24196439 Free PMC article.
16 results