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Selected Ion Monitoring for Orbitrap-Based Metabolomics.
Lu W, McBride MJ, Lee WD, Xing X, Xu X, Li X, Oschmann AM, Shen Y, Bartman C, Rabinowitz JD. Lu W, et al. Among authors: shen y. Metabolites. 2024 Mar 25;14(4):184. doi: 10.3390/metabo14040184. Metabolites. 2024. PMID: 38668312 Free PMC article.
Metabolite discovery through global annotation of untargeted metabolomics data.
Chen L, Lu W, Wang L, Xing X, Chen Z, Teng X, Zeng X, Muscarella AD, Shen Y, Cowan A, McReynolds MR, Kennedy BJ, Lato AM, Campagna SR, Singh M, Rabinowitz JD. Chen L, et al. Among authors: shen y. Nat Methods. 2021 Nov;18(11):1377-1385. doi: 10.1038/s41592-021-01303-3. Epub 2021 Oct 28. Nat Methods. 2021. PMID: 34711973 Free PMC article.
Slow TCA flux and ATP production in primary solid tumours but not metastases.
Bartman CR, Weilandt DR, Shen Y, Lee WD, Han Y, TeSlaa T, Jankowski CSR, Samarah L, Park NR, da Silva-Diz V, Aleksandrova M, Gultekin Y, Marishta A, Wang L, Yang L, Roichman A, Bhatt V, Lan T, Hu Z, Xing X, Lu W, Davidson S, Wühr M, Vander Heiden MG, Herranz D, Guo JY, Kang Y, Rabinowitz JD. Bartman CR, et al. Among authors: shen y. Nature. 2023 Feb;614(7947):349-357. doi: 10.1038/s41586-022-05661-6. Epub 2023 Feb 1. Nature. 2023. PMID: 36725930 Free PMC article.
NAD+ flux is maintained in aged mice despite lower tissue concentrations.
McReynolds MR, Chellappa K, Chiles E, Jankowski C, Shen Y, Chen L, Descamps HC, Mukherjee S, Bhat YR, Lingala SR, Chu Q, Botolin P, Hayat F, Doke T, Susztak K, Thaiss CA, Lu W, Migaud ME, Su X, Rabinowitz JD, Baur JA. McReynolds MR, et al. Among authors: shen y. Cell Syst. 2021 Dec 15;12(12):1160-1172.e4. doi: 10.1016/j.cels.2021.09.001. Epub 2021 Sep 23. Cell Syst. 2021. PMID: 34559996 Free PMC article.
Mitochondrial ATP generation is more proteome efficient than glycolysis.
Shen Y, Dinh HV, Cruz ER, Chen Z, Bartman CR, Xiao T, Call CM, Ryseck RP, Pratas J, Weilandt D, Baron H, Subramanian A, Fatma Z, Wu ZY, Dwaraknath S, Hendry JI, Tran VG, Yang L, Yoshikuni Y, Zhao H, Maranas CD, Wühr M, Rabinowitz JD. Shen Y, et al. Nat Chem Biol. 2024 Mar 6. doi: 10.1038/s41589-024-01571-y. Online ahead of print. Nat Chem Biol. 2024. PMID: 38448734
The small intestine shields the liver from fructose-induced steatosis.
Jang C, Wada S, Yang S, Gosis B, Zeng X, Zhang Z, Shen Y, Lee G, Arany Z, Rabinowitz JD. Jang C, et al. Among authors: shen y. Nat Metab. 2020 Jul;2(7):586-593. doi: 10.1038/s42255-020-0222-9. Epub 2020 Jun 22. Nat Metab. 2020. PMID: 32694791 Free PMC article.
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