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Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes.
Chen Z, Guo X, Tao R, Huyghe JR, Law PJ, Fernandez-Rozadilla C, Ping J, Jia G, Long J, Li C, Shen Q, Xie Y, Timofeeva MN, Thomas M, Schmit SL, Díez-Obrero V, Devall M, Moratalla-Navarro F, Fernandez-Tajes J, Palles C, Sherwood K, Briggs SEW, Svinti V, Donnelly K, Farrington SM, Blackmur J, Vaughan-Shaw PG, Shu XO, Lu Y, Broderick P, Studd J, Harrison TA, Conti DV, Schumacher FR, Melas M, Rennert G, Obón-Santacana M, Martín-Sánchez V, Oh JH, Kim J, Jee SH, Jung KJ, Kweon SS, Shin MH, Shin A, Ahn YO, Kim DH, Oze I, Wen W, Matsuo K, Matsuda K, Tanikawa C, Ren Z, Gao YT, Jia WH, Hopper JL, Jenkins MA, Win AK, Pai RK, Figueiredo JC, Haile RW, Gallinger S, Woods MO, Newcomb PA, Duggan D, Cheadle JP, Kaplan R, Kerr R, Kerr D, Kirac I, Böhm J, Mecklin JP, Jousilahti P, Knekt P, Aaltonen LA, Rissanen H, Pukkala E, Eriksson JG, Cajuso T, Hänninen U, Kondelin J, Palin K, Tanskanen T, Renkonen-Sinisalo L, Männistö S, Albanes D, Weinstein SJ, Ruiz-Narvaez E, Palmer JR, Buchanan DD, Platz EA, Visvanathan K, Ulrich CM, Siegel E, Brezina S, Gsur A, Campbell PT, Chang-Claude J, Hoffmeister M, Brenner H, Slattery ML, Potter JD, Tsilidis KK, Schulze MB, Gunter MJ, Murphy N, Castells A, Castellví-Bel… See abstract for full author list ➔ Chen Z, et al. Among authors: gruber sb. Nat Commun. 2024 Apr 26;15(1):3557. doi: 10.1038/s41467-024-47399-x. Nat Commun. 2024. PMID: 38670944 Free PMC article.
Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC.
Laken SJ, Petersen GM, Gruber SB, Oddoux C, Ostrer H, Giardiello FM, Hamilton SR, Hampel H, Markowitz A, Klimstra D, Jhanwar S, Winawer S, Offit K, Luce MC, Kinzler KW, Vogelstein B. Laken SJ, et al. Among authors: gruber sb. Nat Genet. 1997 Sep;17(1):79-83. doi: 10.1038/ng0997-79. Nat Genet. 1997. PMID: 9288102
Small changes in expression affect predisposition to tumorigenesis.
Yan H, Dobbie Z, Gruber SB, Markowitz S, Romans K, Giardiello FM, Kinzler KW, Vogelstein B. Yan H, et al. Among authors: gruber sb. Nat Genet. 2002 Jan;30(1):25-6. doi: 10.1038/ng799. Epub 2001 Dec 17. Nat Genet. 2002. PMID: 11743581
Prediction of germline mutations and cancer risk in the Lynch syndrome.
Chen S, Wang W, Lee S, Nafa K, Lee J, Romans K, Watson P, Gruber SB, Euhus D, Kinzler KW, Jass J, Gallinger S, Lindor NM, Casey G, Ellis N, Giardiello FM, Offit K, Parmigiani G; Colon Cancer Family Registry. Chen S, et al. Among authors: gruber sb. JAMA. 2006 Sep 27;296(12):1479-87. doi: 10.1001/jama.296.12.1479. JAMA. 2006. PMID: 17003396 Free PMC article.
Pathologic predictors of microsatellite instability in colorectal cancer.
Greenson JK, Huang SC, Herron C, Moreno V, Bonner JD, Tomsho LP, Ben-Izhak O, Cohen HI, Trougouboff P, Bejhar J, Sova Y, Pinchev M, Rennert G, Gruber SB. Greenson JK, et al. Among authors: gruber sb. Am J Surg Pathol. 2009 Jan;33(1):126-33. doi: 10.1097/PAS.0b013e31817ec2b1. Am J Surg Pathol. 2009. PMID: 18830122 Free PMC article.
PTPRJ haplotypes and colorectal cancer risk.
Toland AE, Rozek LS, Presswala S, Rennert G, Gruber SB. Toland AE, et al. Among authors: gruber sb. Cancer Epidemiol Biomarkers Prev. 2008 Oct;17(10):2782-5. doi: 10.1158/1055-9965.EPI-08-0513. Cancer Epidemiol Biomarkers Prev. 2008. PMID: 18843023
337 results